anxiolytics Flashcards
Short acting BZD
Midazolam
Triazolam
Oxazepam
Intermediate acting BZD
Alprazolam
Lorazepam
Nitrazepam
Estazolam
temazepam
Long acting BZD
Diazepam
Clonazepam
Chlordiazepoxide
Flurazepam
Clobazam
Chlorazepate
CYP3A4 inhibitors
grapefruit juice, erythromycin, itraconaozole and ketoconazole
Non-Benzodiazepines
zolpidem, zopiclone, zaleplon, eszopiclone
DRUG INTERACTION OF BARBITURATES
warfarin,oral contraceptives,tolbutamide,theophylline
melatonin
Stimulates MT1 and MT2 receptor subtypes present in suprachiasmatic nucleus of brain to induce and promote sleep and to maintain circadian rhythm of the normal “sleep-awake” cycle
Ramelteon
selective agonist at the MT1 and MT2 receptor
Atypical anxiolytic
buspirone
Selective serotonin reuptake inhibitors
citalopram, escitalopram fluvoxamine paroxetine fluoxetine sertraline
Serotonin- Norepinephrine reuptake inhibitors (SNRIs
duloxetine venlafaxine
Tricyclic antidepressants
amitriptyline imipramine doxepin
β- adrenoceptor antagonists
propranolol
sedative hypnotics
barbiturates
melatonin analogues
non-bzd
bzd
barbiturates
phenobarbitone
mephobarbitone
pentobarbitone
thiopentone
methohexitone