Cholinergic Agonists

Question 1

Carbachol

Answer 1

N=M

• decrease HR so dont give systemically
• used in eye
• will see predominately M activation
• constriction of pupil (rest and digest dont need wide eyes)

Question 2

Nicotine

Answer 2

N»M

- drooling (N receptor on ganglion to activate muscarinic)

Question 3

Bethanechol

Answer 3

M»N

• systemic use will decrease HR (stop it)
• used locally in lungs and heart

Question 4

Organophosphates/carbamate insecticide

Answer 4

N=M
irreversible indirect acting agonist
- AchE inhibitor
- no "off signal"
- very worried about stopping the heart
- use Ach antagonist instead

Question 5

Endrophonium/neostigmine

Answer 5

N=M
Reversible indirect acting agonist
- AchE inhibitor
- used to enhance motor function