Antihypertensive Drugs

Question 1

Prazosin

Answer 1

alpha antagonist
A1»»A2
- antagonism will cause dilation
- cause TPR to drop and diastolic to drop and the systolic will drop

Question 2

Phenozybenzamine

Answer 2

alpha antagonist
A1>A2
- not completely A1 selective
- covalently modifies receptor (irreversible)

Question 3

Phentolamine

Answer 3

Alpha antagonist
A1=A2
- not selective
- A2 antagonist for sedation so this will reverse sedation (problem is it drops BP from A1)

Question 4

Atipamezole & Tolazoline

Answer 4

Alpha antagonist
A2»A1
A2 antagonist = sedation reversal without the BP drop

Question 5

Metoprolol

Answer 5

Beta antagonist
B1»»>B2
- B1 antagonism (decrease HR, pulse pressure, systolic)
- B1 in kidney to antagonize RAAS (drops BP much better)

Question 6

Propranolol

Answer 6

Beta antagonist
B1=B2
- B2 can cause problem: block B2 agonist will be unable to treat for asthma; skeletal muscle blood supply

Question 7

Labetalol & Carvedilol

Answer 7

Mixed Antagonist
B1=B2 >= A1> A2
- less selective
Both B1/B2 and A1 (watch for asthma with B2)
- used in HF (slow down heart and vasodilate to decrease load on heart)

Question 8

What two antagonist drugs reverse sedation? Why would you use one over the other?

Answer 8

Phentolamine

Antipamazole/tolazoline (no A1 antagonism so no BP drop)