Acetylcholine Neurotransmission Drugs

Question 1

Hemicholinium

Answer 1

• inhibits synthesis of Ach

Question 2

Vesamicol

Answer 2

prevent vesicular storage of Ach (reuptake into vesciles)

Question 3

Black widow venom (a-latrotoxin)

Answer 3

increase release of Ach

Question 4

What are two neuromuscular end plate AchE inhibitors?

Answer 4

Endrophonium (reversible)

Insecticide (irreversible)

Question 5

What are two NM antagonists that cause full paralysis? MOA?

Answer 5

Tobocurarine & Pancuronium

• competitively inhibit
• can move but can’t feel anything

Question 6

Ñame 1 NM antagonist that causes muscle paralysis good for emergency intubation?

Answer 6

Succinylcholine

- acts as Ach (binds and prevents activation)