Cholesterol Flashcards

1
Q

What makes up the hydrophobic core?

A

Esterified Cholesterols, Triglycerides

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2
Q

What makes up the hydrophilic coat

A

Amphipathic cholesterol phospholipids apoproteins

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3
Q

What is the function of apoproteins?

A

act as recognition and binding sites allowing lipoproteins to bind to cells

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4
Q

What apoproteins do HDL contain?

A

apoA-1 apoA-II

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5
Q

What apoproteins do LDL contain?

A

apoB-100

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6
Q

What apoproteins do VLDL contain?

A

apoB-100

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7
Q

What apoproteins do chylomicrons contain?

A

apoB-48

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8
Q

Where are chylomicrons formed?

A

In the Enterocytes that line the intestine

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9
Q

Where are VLDL formed?

A

In the liver hepatocytes

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10
Q

What is the function of chylomicrons?

A

Exogenous transport of dietary triglycerides

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11
Q

What is the function of VLDL?

A

Endogenous transport of triglycerides synthesised in the liver

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12
Q

Function of all apoB containing lipoproteins?

A

Transport triglycerides to muscles for ATP biogenesis and adipocytes for storage

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13
Q

Life cycle of lipoproteins

A

Assembly
Intravascular metabolism
Receptor mediated clearance

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14
Q

How are the triglycerides formed?

A

Monoglycerides and free fatty acids diffuse separately across the membrane and combine within the cell

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15
Q

Which protein channel allows cholesterol into the cell?

A

NPCILI Channel

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16
Q

How do lipoproteins exit the cell?

A

Via endocytosis when the correct apoprotein has been synthesised to the surface

17
Q

What must happen to chylomicrons and VLDL to become activated?

A

apoC-II must be transferred from a HDL to allow the lipoproteins to bind to the cell surface and transfer its cargo

18
Q

What receptors on the cell surface do lipoproteins bind to?

A

Lipoprotein Ligase

19
Q

Upon binding to lipoprotein ligase what happens to the VLDL and the chylomicrons?

A

They become remnants depleted in triglycerides which are removed but enriched in esters which stay

20
Q

What occurs when the lipoproteins have dissociated from the LPL?

A

apoC-II transfered for an apoE from a HDL which allows them to bind to the liver.

21
Q

Which receptor do VLDL and chylomicron remnants bind to on the hepatocytes?

A

Hepatic Ligase

22
Q

What happens upon binding to hepatic ligase?

A

VLDL and chylomicrons are further metabolised

All chylomicrons and 50% of VLDL are cleared by endocytosis into the cell

23
Q

What happens to the other 50% of VLDL which bind to hepatic ligase?

A

More triglycerides are removed and enriched in esters increasing density of particle
Lose apoE and gain apoB-100
Now a LDL particle

24
Q

What is LDL endocytosis into a cell reliant on?

A

Presence of Lipoprotein Ligase

25
Q

Upon release of cholesterol esters into the cell what happens?

A

Esters are hydrolysed to form three units of cholesterol

26
Q

What is the effect of increasing intracellular cholesterol levels?

A

Inhibits HMG-CoA reductase reducing synthesis of cholesterol
Down regulates LDL receptor expression
Can be stored as cholesterol ester or precursor for bile salt

27
Q

Function of HDL

A

Accept cholesterol from Macrophages in atheromatous plaques, and from VLL and LDL
Returns cholesterol to the liver where it can be broken down and excreted
Lowers serum cholesterol levels