Cholesterol Flashcards
What makes up the hydrophobic core?
Esterified Cholesterols, Triglycerides
What makes up the hydrophilic coat
Amphipathic cholesterol phospholipids apoproteins
What is the function of apoproteins?
act as recognition and binding sites allowing lipoproteins to bind to cells
What apoproteins do HDL contain?
apoA-1 apoA-II
What apoproteins do LDL contain?
apoB-100
What apoproteins do VLDL contain?
apoB-100
What apoproteins do chylomicrons contain?
apoB-48
Where are chylomicrons formed?
In the Enterocytes that line the intestine
Where are VLDL formed?
In the liver hepatocytes
What is the function of chylomicrons?
Exogenous transport of dietary triglycerides
What is the function of VLDL?
Endogenous transport of triglycerides synthesised in the liver
Function of all apoB containing lipoproteins?
Transport triglycerides to muscles for ATP biogenesis and adipocytes for storage
Life cycle of lipoproteins
Assembly
Intravascular metabolism
Receptor mediated clearance
How are the triglycerides formed?
Monoglycerides and free fatty acids diffuse separately across the membrane and combine within the cell
Which protein channel allows cholesterol into the cell?
NPCILI Channel