Chlamydia

Question 1

Small, gram-negative pathogen. No peptidoglycan in cell walls. Obligate intracellular pathogen. “Energy parasite”

Answer 1

Chlamydiae

Question 2

Leading cause of preventable blindness. Most common agents of sexually transmitted bacterial infections. Causes “walking” pneumonia.

Answer 2

Chlamydial Infections

Question 3

Chlamydial Infection spread by:

Answer 3

Droplet/direct contact. Infects mucosal epithelial cells. Localized (eyes, lungs, genitalia). Fingers, flies, fomites, fornication.

Question 4

Causes Genital tract infections in both men and women, but usually asymptomatic in females. Infected infants get conjunctivitis and pneumonia.

Answer 4

C. Trachomatis infections

Question 5

Transit form of C. Trachomatis. Enters epithelial cells (disguised as nutrients/growth factors/hormones), modifies endocytic vesicle, changes into larger intracellular active organisms (RB).

Answer 5

Elementary body (EB)

Question 6

Chlamydial disease. STD. Systemic, invasive infection apparent in lymph nodes that drain genital tract.

Answer 6

Lymphogranuloma Venerum

Question 7

Most prevalent chlamydial pathogen in human population. Usually asymptomatic or acute respiratory response. Can be directly observed in patients with atherosclerotic heart lesions.

Answer 7

Chlamydophila Pneumoniae

Question 8

Chlamydophila Pneumoniae treatment:

Answer 8

Antimicrobials target metabolic active RB forms.

Question 9

Small gram negative rods. Obligate intracellular bacteria. Zoonoses- infections transmitted from animals to humans. Capable of independent metabolism (not energy parasites)

Answer 9

Rickettsiae

Question 10

Causes Rocky Mountain Spotted Fever. Reservoir in Ticks.

Answer 10

R. Rickettsii

Question 11

Once inside blood, Rickettsiae attaches to ____ cells. And gets extruded from cells through ____

Answer 11

Vascular Endothelial cells (small blood vessels)

Filopodia

Question 12

Obligate intracellular bacteria, transmitted by Lone Star tick. Infects monocytes/macrophages.

Answer 12

Ehrlichia

Question 13

Diagnosis of Rickettsioses:

Answer 13

Problematic (usually too late for antibiotics)

Question 14

Smallest organisms capable of growth on cell-free media. Requires sterol. Lack cell wall. Found in mammals/birds

Answer 14

Mycoplasma

Question 15

Causes atypical (walking) pneumonia and hemolytic anemia. Humans only reservoir.

Answer 15

M. Pneumoniae