Antibiotics

Question 1

Inhibitor of DNA replication by binding to DNA, only active in anaerobic microbes

Answer 1

Metronidazole

Question 2

Antibiotics that affect DNA gyrase

Answer 2

Nalidixic Acid

Quinolones

Question 3

Antibiotic that inhibits RNA polymerase

Answer 3

Rifamycin

Question 4

Penicillin disrupts cell wall synthesis by competing with ______ to be cleaved by enzyme

Answer 4

D-alanine

Question 5

4 ways to achieve selective toxicity:

Answer 5

1. Unique cell wall in microbes
2. Unique enzymes in microbes
3. Unique metabolites
4. Unique ribosome structure

Question 6

This enzyme inactives drugs like Penicillin

Answer 6

Beta-lactamase

Question 7

Some bacteria develop ______ to pump antibiotics out of them (resistance to tetracycline)

Answer 7

Efflux pumps

Question 8

Some bacteria will alter their _____ or _____ pathways to combat antibiotics

Answer 8

Enzyme

Metabolic

Question 9

3 ways antibiotic resistance spreads:

Answer 9

1. Chromosome associated resistance
2. Plasmid mediated resistance
3. Rapid spread of resistance

Question 10

5 Ways Antibiotics inhibit bacteria:

Answer 10

1. Inhibition of cell wall synthesis
2. Disruption of cell membrane function
3. Inhibition of protein synthesis
4. Inhibition of nuclei acid synthesis
5. Action as antimetabolites

Question 11

Disrupts cell membrane, binds to phospholipids

Answer 11

Polymyxin B sulfate

Question 12

Tetracycline inhibits _____ to block the ribosome cycle

Answer 12

Transfer RNAs

Question 13

Para-aminobenzoic acid (PABA) is an ______

Answer 13

Antimetabolite