Chemical Synapse Release Machinery Flashcards
postsynaptic density
active zone
synapse (between pre and postsynaptic neurons)
what is the purpose/significance of astrocytes
-they surround the synapse
-they promote neurotransmitter reuptake from synapse
-they allow for potassium to exit the presynaptic terminal in response to calcium influx
regulated secretory pathway
-a process of exocytosis where NT filled vesicles are stored for later release
-this pathway evolved into the traditional process of synaptic transmission
two changes which allowed for the regulatory secretory pathway to evolve into modern chemical synaptic transmission
-adaptation of small, clear core vesicles
-local vesicle recycling in the endosome (ends need for vesicles to be transported from golgi body)
-both of these makes synaptic transmission much faster
three phases of NT release
docking, priming, fusion
what makes up the SNARE/SNAREpin complex
snap25, syntaxin, synaptobrevin
-“core release machinery”
what makes up the RIM coordinating complex
RIM, RIM BP, munc13
which proteins gate exocytosis
munc18, complexin, and synaptotagmin
describe the process/players involved for docking
describe the process/players involved for priming
describe the process/players involved in priming
perisynaptic zones
where synaptic vesicles are recovered through endocytosis for recycling
-also contain neurotransmitter receptors that modulate synaptic release (use how much nt is present to signal when enough synaptic release has occurred)
