Chapters 48 and 49 Flashcards
Flow of information
dendrite -> cell body -> axon
Dendrite
collects electrical signals
Cell Body
integrates signals and generates an outgoing signal
Axon
passes signals to dendrites of another cell/effector cell
Signals
action potentials (AP)
- goes on in every neuron
- once started, cant be stopped
Resting membrane potential
chemical and electrical driving forces = potential energy
-create a voltage across the membrane
Vm= -70 mV
Chemical driving force for K+
larger
Na+ gradient
Na+ wants to move more
-2 gradients, the bigger gradient wins
Voltage
= current x resistance
Depolarization event in neuron
- Na depolarizes
- Ca releases the NT
- K repolarizes
Na channels
depolarize
-detect the threshold
K channels
repolarize
Synapse
- presynaptic membrane (neuron)
- presynaptic cleft
- postsynaptic membrane (effector cell)
Order of events
- Stimulus
- Graded potential: stimulus to the axon hillock
- Action potential
- Release of NT @ terminus
Ion Channels
-ligand gated on soma
-voltage gated on axon
Na+ or K+ or Ca+ selective
Action potential events
- Vg Na open (Na enters)
-depolarization - Vg Na close
Vg K open (K exits)
-repolarization - Vg K stay open
-hyperpolarization - Vg K close, Na and K leak out
Quanta
unit that NT are released in
All or nothing
AP’s
get the hillock to -55mV
Summation
sum of graded potentials to create an AP
- spatial
- temporal
Temporal summation
increased frequency, get further
Events at synapse
- Excitatory
- Inhibitory