Chapter 9 and 10 Regulatory Strategies

Question 1

ATCase is the start of the biosynthetic pathway of pyrimidine in which the endproduct is ?

Answer 1

CTP

Question 2

CTP is a ? of ATCase

Answer 2

feedback inhibitor

Question 3

feedback inhibitor

Answer 3

end product that inhibits the 1st enzyme

Question 4

ATCase consists of spearable ? and ? subunits

Answer 4

catalytic and regulatory

Question 5

PALA is a ? inhibitor of ATCase

Answer 5

competitive

Question 6

homotropic effector

Answer 6

is a substrate for its target enzyme, as well as a regulatory molecule of the enzyme’s activity

Question 7

heterotropic effector

Answer 7

regulatory molecule that is not also the enzyme’s substrate

Question 8

affect of PALA on ATCase

Answer 8

rxn cannot proceed with inhibitor bound, but causes T to R transition which has higher affinity for substrate

Question 9

CTP is a ? of ATCase

Answer 9

allosteric inhibitor

Question 10

ATP is a ? of ATCase

Answer 10

allosteric activator

Question 11

PALA binds to ? subunit of ATCase

Answer 11

catalytic

Question 12

ATP and CTP bind to ? subunit of ATCase

Answer 12

regulatory

Question 13

isozymes

Answer 13

proteins that catalyze the same reaction

Question 14

lactate dehydrogenase structure

Answer 14

two interchangeable isozymic polypeptide chains. Each with two of either H or M subunits. 5 total combinations.

Question 15

H subunit functions better in ? conditions

Answer 15

aerobic

Question 16

M subunit functions better in ? conditions

Answer 16

anaerobic

Question 17

H and M subunits operate differently due to different ?

Answer 17

Km

Question 18

? phosphorylate target proteins

Answer 18

protein kinases

Question 19

? dephosphoylate proteins

Answer 19

protein phosphatases

Question 20

cAMP activates ?

Answer 20

protein kinase A

Question 21

PKA function

Answer 21

blocks ATP binding

Question 22

activation by cleavage

Answer 22

specific proteolytic cleavage

Question 23

? is an activator of several pancreatic zymogens

Answer 23

Trypsin

Question 24

How do cells turn off activated zymogens

Answer 24

put an inhibitor on active site