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Biol 4880 > Chapter 17 Citric Acid Cycle > Flashcards

Chapter 17 Citric Acid Cycle Flashcards

1
Q

CAC occurs in ? of ?

A

matrix of mitochondria

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2
Q

CAC is anaerobic/aerobic

A

anaerobic

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3
Q

enzyme that bridges glycolysis to CAC

A

pyruvate dehydrogenase

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4
Q

pyruvate dehydrogenase net reaction

A

pyruvate + CoA + NAD+ goes to acetyl CoA +CO2 +NADH + H+

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5
Q

citrate is produced from citrate synthesis using ? and ?

A

Acetyl CoA and oxaloacetate

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6
Q

isomerizes citrate to isocitrate

A

aconitase

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7
Q

isocitrate dehydrogenase net reaction

A

isocitrate + NAD+ + H+ goes to NADH + CO2 + alpha-ketoglutarate

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8
Q

alpha-ketoglutarate dehydrogenase net reaction

A

alpha-ketoglutarate + NAD+ + CoA goes to succinyl CoA + CO2 + NADH

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9
Q

succinyl CoA synthetase net reaction

A

succinyl CoA + Pi + GDP goes to succinate + CoA + GTP

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10
Q

enzymes required to convert succinate to fumarate to malate to oxaloacetate respectively

A

succinate dehydrogenase, fumarase, malate dehydrogenase

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11
Q

enzymes that produce NADH in CAC

A

isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate dehydrogenase

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12
Q

produces FADH2 in CAC

A

succinate dehydrogenase

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13
Q

CAC net reaction

A

acetylCoA + 3NAD+ + FAD + GDP + Pi + 2H2O goes to 2CO2 + 3NADH + FADH2 + GTP + 2H+ + CoA

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14
Q

key regulatory step is ?

A

formation of acetyl CoA by pyruvate dehydrogenase complex (PDH)

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15
Q

PDC activators

A

CoA and NAD+

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16
Q

PDC inhibitors

A

NADH, ATP, Acetyl CoA

17
Q

? refills oxaloacetate from pyruvate

A

pyruvate carboxylase

18
Q

Uses sulfur-iron cluster

A

Aconitase

19
Q

E1,2and 3 subunits of private dehydrogenase

A

Pyruvate dehydrogenase, dihydrolipoyl transacetylase, dihydrolipoyl dehydrogenase

20
Q

Key to substrate channeling

A

Lipoamide arm

21
Q

Molecules between acetyl CoA and oxaloacetate

A

Citrate, isocitrate, a-ketoglutarate, succinyl CoA, succinate, fumarate, malate

Biol 4880 (13 decks)

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