chapter 9 Flashcards

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1
Q

3 pathways when immature lymphocyte recognizes of self antigen in central tolerance (thymus and bone marrow)

A

apoptosis
change in receptors (b cells only)
development of regulatory t lymphocytes (CD4 t cells)

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2
Q

3 pathways in peripheral tolerance when recognition of self antigen occurs

A

anergy
apoptosis
supression

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3
Q

this mech of peripheral t lymphocyte tolerance, TCR does not send activating signals and the t cell engages an inhibitory receptor
(functional unresponsiveness)

A

anergy

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4
Q

this response in peripheral tissue on recognition of self antigens and suppress (inhibits) the activation of lymphocytes that also reognizes these self antigens

A

suppression

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5
Q

regulatory t-cells suppress immune responses by

A
  1. cytokine signaling (inhibits activation of target cells)
  2. CTLA-4 expression (removes B7 from APCs)
  3. high amounts of IL-2 receptor (depletes IL-2 in local area)
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6
Q

3 principle mechanisms of central B lymphocyte tolerance (which are activated by t cells)

A
  1. non-self reactive b cell (receptor editing: expression of new IgV region)
  2. deletion (apoptosis)
  3. anergic b cell (reduced receptor expression, signaling)
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7
Q

unresponsiveness of the immune system to self antigens

A

immunologic tolerance

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