chapter 4 Flashcards
what uses macromolecules (proteins, polysaccharides, lipids, nucleic acids), small chemicals as a form of antigen recognition
b cell receptor (antibody, Ig)
what uses mainly peptides displayed by MHC molecules on APCs as a form of antigen recognition
t cell receptor (TCR)
what uses variable (V) regions of heavy and light chains of membrane Ig to mediate antigen recognition
b cell receptor (antibody, Ig)
what uses variable (V) regions of a and b chains of the TCR to mediate antigen recognition
t cell receptor (TCR)
what are the two isotype of antibodies that function with niave B cell antigen receptors
IgD and IgM
when dealing with B cell receptors for antigens, when switching from IgM and IgD to other isotypes of antibodies, what regions dont change?
this means heavy chain in constant region is the one changing
variable regions dont change
with this, the antigen binding is made up of 3 CDRs in Va and 3 CDRs in Vb
t cell receptor (TCR)
with this, the antigen binding is made up of 3 CDRs in VH and 3 CDRs in VL
Ig (immunoglobulin)
what chain occurs first from maturing from Pro-B to Pre-B in the steps of the maturation and selection of B lymphocytes
heavy chain occurs first
what are the two positive selections in the steps of the maturation and selection of MHC-restricted T lymphocytes
weak recognition of class II MHC + peptide
and
weak recognition of class I MHC + peptide
