chapter 6!

Question 1

what subset of Cd4 helper t cell has the role in disease of autoimmunity; chronic inflammation and target cells are macrophages?

Answer 1

Th1

Question 2

what subset of Cd4 helper t cell has the role in disease of allergy and target cells are eosinophils?

Answer 2

Th2

Question 3

what subset of Cd4 helper t cell has the role in disease of autoimmunity and target cells are neutrophils?

Answer 3

Th17

Question 4

what cytokine’s principle action is t cell proliferation and regulatory t cell survival

Answer 4

IL-2 (Th1)

Question 5

what cytokine’s principle action is activation of macrophages

Answer 5

IFN-y (Th1’s signature cytokine)

Question 6

what cytokine’s principle action is inhibition of T cell activation and differentiation of regulatory t cells

Answer 6

TGF-B
(inhibitor)

Question 7

these subset cells result in classical macrophage activation (enhanced microbial killing)

Answer 7

Th1 cells

Question 8

this subset is induced by microbes/bacteria that are ingested by phagocytes

Answer 8

Th1 cells

Question 9

what are the cytokines that are secreted from the macrophage response when Th1 cells activate them?

Answer 9

TNF, IL-12, IL-1

B7 molecules also have increased expression

Question 10

this subset is induced by parasitic worm infections

Answer 10

th2 cells

Question 11

signature cytokines for th2 cells

Answer 11

IL-4, IL-5, IL-13

Question 12

what is the antibody produce during antibody production in th2 cells

Answer 12

IgE

Question 13

what are the functions of th2 cells

Answer 13

mast cell degranulation, intestinal mucus secretion and peristalsis (gut), and eosinophil activation

Question 14

binding of eosinophils and IgE in th2 cells, will cause

Answer 14

eosinophils to release they granules and promote helminth death

Question 15

th1 cytokine ____ inhibits th2 and th17 developmental possibilities

Answer 15

IFN-y

Question 16

this subset of cd4 t lymphocyte has microbrioal actions such as phagocytosis and killing of bacteria/fungi AND causes inflammation

Answer 16

th1: classically activated macrophage M1

via IFN, and TLR ligands

Question 17

this subset of cd4 lymphocyte has antiinflammatory effects, wound repair, and fibrosis (inhibitions inflammation)

Answer 17

Th2: alternatively activated macrophage (M2)

via IL-13 and IL-4

Question 18

th2 cytokines _____ and ____ inhibit classical macrophage activation (m1)

Answer 18

il-4 and il-13

Question 19

this cd4 t lymphocyte subset’s signature cytokines are IL-17 and IL-22

Answer 19

th17 cells

Question 20

this subet’s major function is recruitment of neutrophils, resulting in inflammation

Answer 20

th17 subset

Question 21

during the development and function of Cd8 cytotoxic t lymphocytes, this facilitates entry of granzymes into the cytosol during CTL activation, granzymes then activate apoptosis.

Answer 21

perforin

Question 22

what additional mechanism is required for CD4+ effector T cell bound to MHC II molecule plus antigen on macrophage to activate the macrophage killing function?

Answer 22

CD40 ligand on t cell binding to CD40 on macrophage