chapter 7 and 8

Question 1

what are the 4 humoral immune outcomes from activation of B lymphocytes

Answer 1

1. antibody secretion
2. isotype switching
3. affinity maturation
4. memory B cell

Question 2

t-dependent vs. t-independent

Answer 2

t-dependent requires helper t-cell help and can do isotype switching
high affinity

t-independent mainly IgM and low affinity

Question 3

C3a:
C3b:
C5a:
C6-9:

Answer 3

C3a: inflammation
C3b:opsonization and phagocytosis
C5a: inflammation
C6-9:lysis of microbe

Question 4

activated t cells that recognize antigen presented on B cells use _____ ligand and cytokines to activate the B cell

Answer 4

CD40

Question 5

____is the enhancement of phagocytosis by binding of IgG-coated microbes to Fc receptors on phagocytes

Answer 5

opsonization

Question 6

the classical pathway of the complement system starts with recognition of antigen-engaged antibodies by

Answer 6

complement C1 protein

Question 7

what anatomical region is normally protected from pathogens only by humoral immune response and not by cell-mediated immune response

Answer 7

intestinal lumen

Question 8

isotype switching on occurs in what b cells

Answer 8

activated b cells

Question 9

what events occur within germinal centers

Answer 9

1. somatic mutation of Ig V genes
2. generation of memory b cells
3. b cell proliferation
4. affinity maturation

Question 10

what pathogens evade cell-mediated immunity by inhibiting phagosomal-lysosomal fusion?

Answer 10

mycobacteria

Question 11

intracellular bacteria/microbes

Answer 11

Th1

Question 12

helminths

Answer 12

Th2

Question 13

extracellular bacteria/fungi

Answer 13

Th17