Chapter 8; Cardiovascular Drugs Flashcards
Increasing the Force
Positive Inotropes
Cardiac glycosides
Adrenergic drugs
Benzimidazole-pyridazones
Increasing the Force: Cardiac glycosides
Digitalis drugs e.g. digoxin
Increasing the Force: Adrenergic Drugs
epinephrine
Non-selective for alpha 1, beta 1 and beta 2 receptors
Side effect: arrhythmias and hypertension
IV or IT (1:10 000 dilution)
Increasing the Force: Adrenergic Drugs
dopamine
Norepinephrine precursor
non-selective for aplha 1 and beta 1 receptors
IV
Increasing the Force: Adrenergic Drugs
dobtamine
Selective for beta 1 receptor
IV
Increasing the Force: Benzimidazole-pyridazones
pimobendin (VETmedin)
Approved drugs for dogs
increases ventricular contractility by sensitizing cariac muscle to calcium
Vasodilator - descreased preload and afterload
CHF - valvular insufficiency, dilated cardiomyopthy
Chewable tablets
Fixing the Rythm
Antiarrhythmic Drugs
Local Anaesthetics
Beta Blockers
Calcium Channel Blocker
Fixing the Rythm: Local Anaesthetics
lidocaine
Acture, emergency situations
Affects the action potential of cardiac cells, prevents Na++ infulx into myocardial cell during depolarization
IV
Fixing the Rythm: Beta Blocker
propranolol
selective antagonist of beta 1 and beta 2 receptors
IV or tablets
Side effects: bradycardia, bronchoconstriction, weakness
Fixing the Rythm: Calcium Channel Blocker
diltiazem
Block Ca++ channels od the myocardial call at SA and AV node
Tablets
Side effect: hyoptension
Correction Constriction
Vasodilators
Angiotensin-Converting Enzyme Inhibitors
Calsium Channel Blockers
Correction Constriction: Angiotensin-Converting Enzyme Inhibitors
enalapril (Encard) and benazepril (Fortekor)
Approved drug for dogs and cats
Prevent the conversion of angiotensin i to angiotensin ii
Tablets
Side effect: hyptension
Correction Constriction: Calcium Channel Blockers
amlodipine
Inhibits the movement of calcium through channels across myocardial cell membranes and vascular smooth muscle
Peripheral ateries dilate
Tablets
Side effect: hypertension in cats
Losing Fluid
Diuretics
Loop diuretics - furosemide
Potassium sparing diurtics - spironolactone