Chapter 74: Aminoglycosides: Bacteriostatic Inhibitors of Protein Synthesis

Question 1

aminoglycosides

Answer 1

Gentamicin, ​

Neomycin, ​

Amikacin, ​

Tobramycin​
Only IV, Tobramycin can be aerosolized​

Streptomycin,

GNATS

Question 2

amino uses

Answer 2

Most commonly used for serious infections caused by gram negative rods (including pseudomonas, Klebsiella, Serratia, E coli).​

Development of resistance is uncommon (especially with amikacin)​

Needs concentration monitoring​

Use limited by relatively serious toxicities (Ototoxicity nephrotoxicity).​ Hearing loss can be irreversible.

Poor lung penetration​

Question 3

AG therapuetic goal

Answer 3

Treatment of serious infections caused by gram negative bacteria. ​

Question 4

AG baseline data

Answer 4

Blood and or urine cultures

Question 5

AG monitoring

Answer 5

Aminoglycoside levels (peak and troughs) and renal function must be monitored. ​

Question 6

AG identifying high risk pt

Answer 6

Use cautiously in renal impaired patient, pre existing hearing impairment, and those receiving ototoxic and nephrotoxic drugs​

Question 7

AG evaluating therapeutic effects

Answer 7

Monitor for reduction in bacterial symptoms: fever edema, pain, inflammation

Question 8

AG min adverse effects

Answer 8

Use cautiously in renal impairment. Patient must report hearing loss​