Chapter 22: Drugs For Muscle Spasm And Spasticity

Question 1

Muscle relaxants

Answer 1

Decrease mm tone
Used to treat: muscle spasms, pain, hyperreflexia

2 Types:
1. spasmolytics -work centrally, level of spinal cord or brain
2. NM blockers -work peripherally, block N1 receptors in NMJ to stop skel contractions. Used during surgery and procedures such as intubation to cause short term flaccid paralysis

Question 2

Spasmolytics

Answer 2

Indication: tx of painful musculoskeletal conditions ex. Mm spasms asso with overexertion, spasticity asso with MS and CP. These drugs work best with PT.

Question 3

Diazepam

Answer 3

o MOA: Binds to GABA an increase it to increase CL
o Use: Muscle spasms

Question 4

Tizanidine (zanaflex)

Answer 4

o MOA: Alpha 2 agonists (decreases excitatory NTM)
o Treats spasms associate with MS

Question 5

Baclofn (lioresol)

Answer 5

o MOA: Activation of GABA to increase K
o Use: Spasm from spinal cord injury

Question 6

Dantrolene

Answer 6

o MOA: Ryanodine Receptor Antagonist (prevents release of CA and then muscle contraction) in skel mm, blocks ryr1
o Use: Treats muscle spasms associated with MS, CP , SCI, MH

Question 7

Drug used for local muscle spasm asso with overexertion or injuries

Answer 7

1. carisoprodol
2. cyclodenzapine
3. metaxalone
4. chlorozoxazone
5. orphenadrine
   MOA: Act in brainstem

Question 8

CNS muscle relaxants SE

Answer 8

Euphoria, lightheadedness, dizziness muscle weakness.