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My Packs: (WIZEPREP) (BIO 2382) > Chapter 7: 7.3 Signal Transduction Pathways > Flashcards

Chapter 7: 7.3 Signal Transduction Pathways Flashcards

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1
Q

Overview:

Once the ligand is bound, what does the receptor do?

A

Send intracellular signal

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2
Q

Overview:

What happens to the intracellular signal that the receptor releases?

A

Goes through several intermediate receptors
* Transducers

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3
Q

Overview:

How can the activation of transducers happen?

A
  1. Chemical modification
  2. Trigger the production of a second ligand (second messenger)
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4
Q

Transduction by Chemical Modification:

What is the mechanism of this method of signal transduction?

A

A chemical group is added and removed to change the state of the receptor from active to inactive

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5
Q

What is an example of transduction by chemical modification?

A
  • Phosphorylation
  • Methylation
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6
Q

Transduction by Second Messenger:

What is the mechanism of this signal transduction method?

A

The first ligand triggers the production of a second ligand to continue the pathway

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7
Q

Transduction by Second Messenger:

Characteristics of second messenger

A
  • Produced intracellularly
  • Binds to an intracellular receptor
  • Usually small, non-protein molecule (e.x. Ca2+ ions)
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8
Q

What is another example of second messenger signal transduction?

A

Cyclic AMP (cAMP)
* Produced by adenosine cyclase converts energy ATP to cAMP
* Activates PKA, phosphorylates its target to activate the response

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9
Q

Case Study: CREB Signaling

Which receptors does it use?

A

Can use any of the three types of receptors

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10
Q

Case Study: CREB Signaling

What receptors are used in this pathway?

A
  1. Ion channel
  2. RTK
  3. GPCR
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11
Q

Case Study: CREB Signaling

Ion channel function

A
  • Transports calcium ions
  • Ions activate CaMK11 that phosphorylates CREB
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12
Q

CaMK11

A

Kinase

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13
Q

CREB

A

Transcriptional factor

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14
Q

Case Study: CREB Signaling

RTK

A
  • Recognizes growth factors
  • Activates Ras or P13K
  • Leads to CREB phosphorylation
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15
Q

Ras

A

GTPase

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16
Q

P13K

A

Kinase

17
Q

Case Study: CREB Signaling

GPCR

A
  • Recognizes neurotransmitters to activate adenylyl cyclase to produce cAMP
  • cAMP activates PKA to phosphorylate and activate CREB
18
Q

CREB Signalling Pathway

A

My Packs: (WIZEPREP) (BIO 2382) (27 decks)

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