Chapter 53: Acute & Critical Care Medicine Flashcards
Which fluids are less costly and generally have fewer side adverse reactions - crystalloids or colloids
Crystalloids
Colloids are ____ molecules (typically protein or starch) dispersed in solutions that primarily remain in the ______ space and ____ oncotic pressure
Large molecules
intravascular space
Increase
Which fluid is used when water is needed intracellularly, as these products contain “free water”
Dextrose
Which fluids are the most common drugs used for volume resuscitation in shock states
Lactated Ringers and Normal saline
Which fluid is the most commonly used colloid
Albumin
When is albumin useful
significant edema (e.g., cirrhosis)
Boxed warning for hydroxyethyl starch
avoid use in critical illness (including sepsis) due to mortality and renal injury
Which common fluids are crystalloids
D5W
Normal saline
Lactated Ringers
Multiple electrolyte injection (i.e., Plasma-Lyte A)
Which common fluids are colloids
Albumin 5%, 25% (Albutein, AlbuRx)
Dextran
Hydroxyethyl starch
Hyponatremia is Na below
< 135 mEq/L
How do you treat hypotonic hypovolemic hyponatremia
administer sodium chloride IV solutions
How do you treat hypotonic hypervolemic hyponatremia
Diuresis with fluid restriction (since it is caused by fluid overload)
What drugs/drug class can be used to treat SIADH and hypervolemic hyponatremia
Arginine vasopressin (AVP) receptor antagonists Conivaptan and tolvaptan
Correcting sodium more rapidly than ___ mEq/L over ___ hrs can cause ______ or _____, which can cause paralysis, seizures, & death
12 mEq/L over 24 hrs
osmotic demyelination syndrome (ODS) or central pontine myelinolysis
Tolvaptan brand name
Samsca
Tolvaptan is limited to how many days and why
less than 30 days due to hepatotoxicity
Where must tolvaptan be initiated and re-initiated
In a hospital
Side effects of tolvaptan
Thirst, nausea, dry mouth, polyuria
Tolvaptan monitoring
Rate of Na increase
Hypernatremia is sodium greater than ____ mEq/L
145 mEq/L
Hypokalemia is potassium less than ___ mEq/L
3.5 mEq/L
Medications that can cause hypokalemia
amphotericin, insulin
A drop of 1 mEq/L in serum K below 3.5 mEq/L represents a total body deficit of ___-___ mEq
100-400 mEq
Through a peripheral line, IV potassium replacement includes a max infusion rate of < / = ___ mEq/hr & a max concentration of ___ mEq/___ mL
10 mEq/hr
10 mEq/100 mL
IV potassium can be fatal if administered in which ways
undiluted or IV push
When hypokalemia is resistant to treatment, what should be checked
serum magnesium
What is necessary for potassium uptake
Magnesium
When serum Mg is < __ mEq/L with life-threatening symptoms (seizures & arrhythmias), what is recommended
< 1 mEq/L
IV magnesium sulfate
When serum Mg is > 1 mEq/L without life-threatening symptoms, what can be used
oral magnesium oxide
When is hypophosphatemia considered severe
When serum phosphate is < 1 mg/dL
When serum PO4 is < 1 mg/dL, what is used for replacement
IV Phosphorous
What does IV immune globulin contain
Pooled immunoglobulin (IgG)
What are some off-label uses for IVIG
MS, myasthenia gravis, Guillain-Barre
IVIG brand names
Carimune NF, Flebogamma DIF, Gamunex-C, Octagam, Privigen
When should a slower infusion rate be used with IVIG
In renal and CV disease
IVIG boxed warnings
- Acute renal dysfunction - rare, but fatal (more likely with products stabilized with sucrose)
- Thrombosis (even without risk factors)
IVIG boxed warnings
HA, nausea, diarrhea, injection site reaction, infusion reaction (facial flushing, chest tightness, fever, chills, hypotension - slow/stop infusion)
What is the scoring tool used to determine prognosis and estimate ICU mortality risk
The Acute Physiologic Assessment & Chronic Health Evaluation II (APACHE II)
Most vasopressors work by stimulating alpha receptors, which causes _______ & (increases/decreases) systemic vascular resistance (SVR), which increases ____
Vasoconstriction (think vasopressor PRESSES down on the vasculature)
Increases
BP
_____ is a natural precursor of NE and is recommended for use in symptomatic bradycardia
Dopamine
Low (renal) dopamine dose (DA-1 agonist)?
1-4 mcg/kg/min
Medium dopamine dose (beta-1 agonist)?
5-10 mcg/kg/min
High dopamine dose (alpha-1 agonist)?
10-20 mcg/kg/min
Epinephrine MOA
Alpha-1, beta-1, beta-2 agonist
Norepinephrine brand name
Levophed
Norepinephrine MOA
Alpha-1 agonist > beta-1 agonist
Phenylephrine MOA
Alpha-1 agonist
What are the other names for vasopressin
ADH and arginine vasopressin (AVP)
All vasopressors are ____ when administered IV
Vesicants
How should vasoconstrictor extravasation be treated
phentolamine
Vasopressor side effects
Arrhythmias, tachycardia (esp DA, Epi, and vasopressin), necrosis (gangrene), bradycardia (phenylephrine), hyperglycemia (epi)
What should be monitored with all vasopressors
BP
How should all vasopressors be administered
central IV line
Dose of epinephrine used for IV push
0.1 mg/mL (1:10,000 ratio strength)
Dose of epinephrine used for IM injection
1 mg/mL (1:1,000 ratio strength)