Chapter 45: Thyroid Disorders Flashcards
Which thyroid hormone is more potent, but has a shorter half-life
T3
Free ___ is the unbound, active form that is monitored in patients with thyroid disorders
T4
Hypothyroidism = ↓ __ & ↑ __
↓ T4 & ↑ TSH
Most common cause of hypothyroidism
Hashimoto’s disease (autoimmune)
What is an uncommon, but potentially fatal complication of hypothyroidism
Myxedema coma
Initial treatment for myxedema coma
IV levothyroxine
What are s/sx of hypothyroidism
- Cold intolerance/sensitivity
- Dry skin, coarse hair or loss of hair
- Fatigue; weakness
- Muscle cramps; myalgia
- Voice changes
- Constipation
- Weight gain
- Goiter
- Depression; memory & mental impairment
- Bradycardia
- Menorrhagia
Key drugs and conditions that can cause hypothyroidism
- Remember: I TALC*
- Interferons (also hyperthyroid)
- TKIs (e.g., sunitinib)
- Amiodarone (also hyperthyroid)
- Lithium
- Carbamazepine
- Conditions: Hashimoto’s Disease
TSH level and symptoms should be monitored every __-__ weeks until levels are normal
4-6 weeks
Too high of a thyroid hormone replacement dose in elderly patients can cause what conditions
Afib and fractures
What is the drug of choice for hypothyroidism
Levothyroxine (T4)
Levothyroxine brand name
Synthroid, Levoxyl, Unithroid
Where should you check for therapeutic equivalencies of a generic brand of levothyroxine
Orange book
Full replacement dose of levothyroxine is ___ mcg/mg/day (IBW)
1.6
If known CAD, start with __-__ mcg daily of levothyroxine
12.5-25
Thyroid, desiccated (T3 & T4) brand name
Armour Thyroid