Chapter 5 - viruses Flashcards

1
Q

Viruses are _____________ ________ _________ (meaning they cannot function outside of a host cell).

A

intracellular obligate parasites

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2
Q

Viruses are typically between __ and ___ nanometers.

A

10 and 100

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3
Q

Virus genomes are typically between a few thousand to ______ nucleotides in length.

A

200,000

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4
Q

Viruses may contain ______ OR _______-stranded DNA or RNA.

A

single or double

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5
Q

The protein shell around a genome is called a ______.

A

capsid

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6
Q

Capsids are composed of many __________ proteins.

A

capsomere

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7
Q

When a capsid and genome are together, the structure is called a ____________.

A

nucleocapsid

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8
Q

Viruses could possibly have an ________ (plasma membrane taken from a host cell around the capsid).

A

envelope

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9
Q

Capsids often exhibit either _______ or ___________ (sometimes called polyhedral) shapes.

A

helical, icosahedral

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10
Q

If a plasma membrane surrounds the nucleocapsid, the virus is “_________.”

A

enveloped

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11
Q

If there is no plasma membrane, the virus is “_____.”

A

naked

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12
Q

Enveloped viruses are mostly associated with _______ (including ______) as their hosts.

A

animals, humans

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13
Q

A virus must:
- stick to a host cell (______)
- get into the cell (_________) and release its genome (______)
- express its genes to make proteins (_________)
- replicate its genome (_________)
- put everything together (________) and get the new virus particles out (____)

A

adhere, penetrate, uncoat, synthesis, synthesis, assembly, exit

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14
Q

In the replication cycle, _____ is arguably the most important part in the viral replication cycle.

A

entry

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15
Q

_________ for entry vary depending on the host cell (animal viruses don’t have to contend with a cell wall structure)

A

mechanisms

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16
Q

The most common mode of entry int an animal cell is ________ ______ of an enveloped virus.

A

membrane fusion

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17
Q

Viruses can enter into animal cells through ________ ______ and ___________ of an enveloped or non-enveloped virus.

A

membrane fusion, endocytosis

18
Q

Entry into _____ cells depend on damage to tissues and open spots in the cell wall.

19
Q

These factors can allow for viruses to enter into plant cells:

A

insects feeding on plants
wind damage
hail/rain damage
fire damage
human-induced damage

20
Q

Viruses enter into ________ by punching a hole into the cell wall and transferring DNAA through the hole.

21
Q

In _____ replication cycle, phages replicate inside host cells and burst open/lyse them to spread.

22
Q

In _________ replication cycles, the phages integrate their genome into the host cell’s genome and is replicated each time the host cell replicates.

23
Q

When a phage integrates their genome into the bacterial host cells genome, it becomes a ________.

24
Q

To cultivate animal viruses, ______ _______ of host cells must be used to grow the targets for the viruses.

A

tissue culture

25
Tissue cultures must be kept _______ and ________-____.
sterile, bacteria-free
26
Structural changes in host cells that are caused by viral infections.
cytopathic effects (CPE)
27
Viral ______________ is the measurement of the quantity of a virus.
quantification
28
Viruses are usually measured as a _____, or concentration of a virus preparation.
titer
29
Method of viral quantification where one counts the viruses within the material and scaling up to determine titer.
direct count
30
Method of viral quantification that is useful in phages and plant viruses.
plaque assay
31
The ____ ______________ ______ classify viruses based on Order, Family, Subfamily, Genus, and Species.
ICTV classification scheme
32
ICTV =
International Committee on Taxonomy of Viruses
33
The _________ ______________ ______ is based around mRNA production methods and separates viruses into seven classes.
Baltimore classification system
34
_______ consists only of naked RNA (infectious RNA strands).
viriods
35
Viroids are only a=observed to cause disease in ______.
plants
36
_________ viruses require a helper virus for their replication (e.g. hepatitis).
satellite
37
Satellite ____ also require helper virus for replication.
RNAs
38
______ are thought to revolve around conversion of protein conformations from normal to abnormal form over time.
Prions
39
Prions are responsible for _____________ ___________ ________________ (TSEs), such as mad cow disease and kuru.
transmissible spongiform encephalopathies
40
Viruses are exploited to deliver working copies of genes to replace damaged versions =
gene therapy