CHAPTER 4_HEMATOPOIESES Flashcards
- The normal sequence of blood cell development is
A. yolk sac—red bone marrow—liver and spleen
B. yolk sac—thymus—liver and spleen—red bone
marrow
C. yolk sac—liver and spleen—red bone marrow
D. liver and spleen—yolk sac—red bone marrow
C. yolk sac—liver and spleen—red bone marrow
- The cell maturation sequence of the segmented
neutrophil is
A. promyelocyte—myeloblast—myelocyte—
metamyelocyte—band or stab—segmented neutrophil
(PMN)
B. myeloblast—promyelocyte—myelocyte—
metamyelocyte—band or stab—segmented neutrophil
(PMN)
C. monoblast—promyelocyte—myelocyte—
metamyelocyte—band or stab—segmented neutrophil
(PMN)
D. promyelocyte—myelocyte—metamyelocyte—band
or stab—segmented neutrophil (PMN)
B. myeloblast—promyelocyte—myelocyte—
metamyelocyte—band or stab—segmented neutrophil
(PMN)
- The maturational sequence of the thrombocyte
(platelet) is
A. megakaryoblast— promegakaryocyte—
megakaryocyte—metamegakaryocyte—thrombocyte
B. promegakaryocyte—megakaryocyte
metamegakaryocyte—thrombocyte
C. megakaryoblast—promegakaryocyte
megakaryocyte—thrombocyte
D. megakaryoblast—promegakaryocyte—
metamegakaryocyte—thrombocyte
C. megakaryoblast—promegakaryocyte
megakaryocyte—thrombocyte
- The maturational sequence(s) of the erythrocyte is
(are)
A. rubriblast—prorubricyte—rubricyte—
metarubricyte—reticulocyte—mature erythrocyte
B. prorubricyte—rubricyte—metarubricyte—
reticulocyte—mature erythrocyte
C. pronormoblast—basophilic normoblast—
polychromatophilic normoblast—orthochromic
normoblast—reticulocyte—mature erythrocyte
D. both A and C
D. both A and C
- As a blood cell matures, the overall cell diameter in
most cases
A. increases
B. decreases
C. remains the same
B. decreases
- As a blood cell matures, the ratio of nucleus to
cytoplasm (N:C) in most cases
A. increases
B. decreases
C. remains the same
B. decreases
- The chromatin pattern, in most cells, as the cell
matures
A. becomes more clumped
B. becomes less clumped
C. remains the same
A. becomes more clumped
- The presence of nucleoli is associated with
A. immature cells
B. all young cells, except myeloblasts
C. only erythroblasts
D. disintegrating cells
A. immature cells
- In the blast stage of development of leukocytes, the
cytoplasm of the cell is
A. dark blue and lacks vacuoles
B. light blue and lacks granules
C. light blue and has specific granules
D. gray with many dark-blue granules
B. light blue and lacks granules
Questions 10 through 14: Match the cellular
characteristics with the name of the appropriate mature
leukocyte. Use an answer only once.
A. Large orange granules
B. An elongated and curved nucleus
C. Light, sky-blue cytoplasm
D. Kidney bean–shaped nucleus
E. Averages approximately 56% of normal adult
leukocytes in the peripheral blood
- __D___ Monocyte
Questions 10 through 14: Match the cellular
characteristics with the name of the appropriate mature
leukocyte. Use an answer only once.
A. Large orange granules
B. An elongated and curved nucleus
C. Light, sky-blue cytoplasm
D. Kidney bean–shaped nucleus
E. Averages approximately 56% of normal adult
leukocytes in the peripheral blood
- __E___ Segmented neutrophil
Questions 10 through 14: Match the cellular
characteristics with the name of the appropriate mature
leukocyte. Use an answer only once.
A. Large orange granules
B. An elongated and curved nucleus
C. Light, sky-blue cytoplasm
D. Kidney bean–shaped nucleus
E. Averages approximately 56% of normal adult
leukocytes in the peripheral blood
- __C___ Lymphocyte
Questions 10 through 14: Match the cellular
characteristics with the name of the appropriate mature
leukocyte. Use an answer only once.
A. Large orange granules
B. An elongated and curved nucleus
C. Light, sky-blue cytoplasm
D. Kidney bean–shaped nucleus
E. Averages approximately 56% of normal adult
leukocytes in the peripheral blood
- __B___ Band form neutrophil
Questions 10 through 14: Match the cellular
characteristics with the name of the appropriate mature
leukocyte. Use an answer only once.
A. Large orange granules
B. An elongated and curved nucleus
C. Light, sky-blue cytoplasm
D. Kidney bean–shaped nucleus
E. Averages approximately 56% of normal adult
leukocytes in the peripheral blood
- __A___ Eosinophil
- The progression of erythropoiesis from prenatal life
to adulthood is
A. yolk sac—red bone marrow—liver and spleen
B. yolk sac—liver and spleen—red bone marrow
C. red bone marrow—liver and spleen—yolk sac
D. liver and spleen—yolk sac—red bone marrow
B. yolk sac—liver and spleen—red bone marrow
- Which of the following is (are) characteristic(s) of
erythropoietin?
A. Glycoprotein
B. Secreted by the liver
C. Secreted by the kidneys
D. All of the above
D. All of the above
- Which of the following is a characteristic of
erythropoietin?
A. Produced primarily in the liver of the unborn
B. Gene for erythropoietin is found on chromosome 11
C. Most erythropoietin is secreted by the liver in adults
D. Cannot cross the placenta barrier
A. Produced primarily in the liver of the unborn
- Stimulation of erythropoietin is caused by
A. tissue hypoxia
B. hypervolemia
C. inflammation
D. infection
A. tissue hypoxia
- The maturational sequences of an erythrocyte are
A. rubriblast—prorubricyte—metarubricyte—
rubricyte-reticulocyte
B. rubriblast—prorubricyte—rubricyte—metarubricyte
reticulocyte
C. pronormoblast—basophilic normoblast—
polychromatic normoblast—orthochromatic
normoblast—reticulocyte
D. both B and C
D. both B and C
- What is the immature erythrocyte found in the bone
marrow with the following characteristics: 12 to 17 mm
in diameter, N:C of 4:1, nucleoli not usually apparent,
and basophilic cytoplasm?
A. Rubriblast (pronormoblast)
B. Reticulocyte
C. Metarubricyte (orthochromatic normoblast)
D. Prorubricyte (basophilic normoblast)
D. Prorubricyte (basophilic normoblast)
- The nucleated erythrocyte with a reddish pink
cytoplasm and condensed chromatin pattern is a
A. rubricyte (polychromatic normoblast)
B. basophilic normoblast (prorubricyte)
C. metarubricyte (orthochromatic normoblast)
D. either B or C
C. metarubricyte (orthochromatic normoblast)
- With a normal diet, an erythrocyte remains in the
reticulocyte stage in the circulating blood for
A. 1 day
B. 2.5 days
C. 3 days
D. 120 days
A. 1 day
- In a Wright-stained peripheral blood film, the
reticulocyte will have a blue appearance. This is referred
to as
A. megaloblastic maturation
B. bluemia
C. polychromatophilia
D. erythroblastosis
C. polychromatophilia
- In the reticulocyte stage of erythrocytic
development,
A. nuclear chromatin becomes more condensed
B. RNA is catabolized and ribosomes disintegrate
C. full hemoglobinization of the cell occurs
D. both B and C
D. both B and C
- On a Wright-stained peripheral blood smear, stress
or shift reticulocytes are
A. smaller than normal reticulocytes
B. about the same size as normal reticulocytes
C. larger than normal reticulocytes
D. noticeable because of a decreased blue tint
C. larger than normal reticulocytes
- The normal range for reticulocytes in adults is
A. 0% to 0.5%
B. 0.5% to1.0%
C. 0.5% to2.0%
D.1.5% to2.5%
C. 0.5% to2.0%
- If a male patient has a reticulocyte count of 5.0%
and a packed cell volume of 0.45 L/L, what is his
corrected reticulocyte count?
A.2.5%
B.4.5%
C. 5.0%
D. 10%
C. 5.0%
- If a male patient has a reticulocyte count of 6.0%
and a packed cell volume of 45%, what is his RPI?
A.1.5
B.3.0
C.4.5
D.6.0
D.6.0
- Normal adult hemoglobin has
A. two alpha and two delta chains
B. three alpha and one beta chains
C. two alpha and two beta chains
D. two beta and two epsilon chains
C. two alpha and two beta chains
- The number of heme groups in a hemoglobin
molecule is
A. 1
B. 2
C. 3
D. 4
D. 4
- Increased amounts of 2,3-DPG _____ the oxygen
affinity of the hemoglobin molecule.
A. increases
B. decreases
C. does not alter
B. decreases
- After a molecule of hemoglobin gains the first two
oxygen molecules, the molecule
A. expels 2,3-DPG
B. has decreased oxygen affinity
C. becomes saturated with oxygen
D. adds a molecule of oxygen to an alpha chain
A. expels 2,3-DPG
- If normal adult (A1) and fetal hemoglobin F are
compared, fetal hemoglobin has _____ affinity for
oxygen.
A. less
B. the same
C. a greater
C. a greater
- Oxyhemoglobin is a _____ than deoxyhemoglobin.
A. weaker acid
B. stronger acid
B. stronger acid
Questions 22 and 23: The initial condensation reaction
in the synthesis of porphyrin preceding heme formation
takes place in the (22) _____ and requires (23) _____.
- _____
A. liver
B. spleen
C. red bone marrow
D. mitochondria
D. mitochondria
- Heme is synthesized predominantly in the
A. liver
B. red bone marrow
C. mature erythrocytes
D. both A and B
D. both A and B
Questions 22 and 23: The initial condensation reaction
in the synthesis of porphyrin preceding heme formation
takes place in the (22) _____ and requires (23) _____.
- _____
A. iron
B. vitamin B6
C. vitamin B12
D. vitamin D
B. vitamin B6
- The final steps in heme synthesis, including the
formation of protoporphyrin, take place in
A. a cell’s nucleus
B. a cell’s cytoplasm
C. the spleen
D. the mitochondria
D. the mitochondria
- An acquired disorder of heme synthesis is
A. congenital erythropoietic porphyria
B. lead poisoning
C. hemolytic anemia
D. hemoglobinopathy
B. lead poisoning
- The protein responsible for the transport of iron in
hemoglobin synthesis is
A. globin
B. transferrin
C. oxyhemoglobin
D. ferritin
B. transferrin
Questions 27 and 28: If globin synthesis is insufficient in
a person, iron accumulates in the cell’s (27) _____ as
(28) _____ aggregates.
- _____
A. nucleus
B. cytoplasm
C. Golgi apparatus
D. mitochondria
B. cytoplasm
Questions 27 and 28: If globin synthesis is insufficient in
a person, iron accumulates in the cell’s (27) _____ as
(28) _____ aggregates.
- _____
A. transferrin
B. ferritin
C. albumin
D. iron
B. ferritin
- Increased erythropoietin production in secondary
polycythemia can be caused by
A. chronic lung disease
B. smoking
C. renal neoplasms
D. all of the above
D. all of the above
- Relative polycythemia exists when
A. increased erythropoietin is produced
B. the total blood volume is expanded
C. the plasma volume is increased
D. the plasma volume is decreased
D. the plasma volume is decreased
- Which of the following is (are) characteristic(s) of
megaloblastic maturation?
A. Cells of some leukocytic cell lines are smaller than
normal
B. Nuclear maturation lags behind cytoplasmic
maturation
C. Cytoplasmic maturation lags behind nuclear
maturation
D. Erythrocytes are smaller than normal
B. Nuclear maturation lags behind cytoplasmic
maturation
Questions 32 and 33: When porphyrin synthesis is
impaired, the (32) _____ become encrusted with (33)
_____.
- _____
A. lysosomes
B. nucleoli
C. mitochondria
D. vacuoles
C. mitochondria
Questions 32 and 33: When porphyrin synthesis is
impaired, the (32) _____ become encrusted with (33)
_____.
- _____
A. protoporphyrin
B. hemoglobin
C. iron
D. delta-aminolaevulinic acid
C. iron