Chapter 43- Antihistamines

Question 1

What first generation H1 antihistamine is the most sedating

Answer 1

Diphenhydramine

Question 2

What is a contraindication for diphenhydramine use

Answer 2

Newborns or premature infants, nursing mothers

Question 3

What plasma drug levels can diphenhydramine increase the levels of, leading to increased risk of arrhythmias

Answer 3

Thioridazine

Question 4

What are some contraindications for brompheniramine use

Answer 4

Concurrent MAOI use, focal CNS lesions,

Question 5

What is a contraindication to phenindamine use

Answer 5

Children under 12

Question 6

What are some additional side effects seen with promethazine use

Answer 6

Photosensitivity and jaundice

Question 7

What is promethazine primarily used for

Answer 7

To relieve preoperative anxiety and reduce postoperative nausea and vomiting

Question 8

What is a contraindication for hydroxyzine use

Answer 8

Early pregnancy

Question 9

What piperazine is a potent antipruritic agent

Answer 9

Hydroxyzine

Question 10

What are the clinical uses of doxepin

Answer 10

Anxiety, depression, pruritis

Question 11

What are the clinical applications of cetirizine, levocetirizine

Answer 11

Allergic rhinitis, urticaria

Question 12

What are some contraindications for acrivastine use

Answer 12

Concurrent MAOI therapy, severe coronary artery disease

Question 13

What is a contraindication for levocabastine use

Answer 13

Soft contact lens

Question 14

What are some additional side effects seen with azelastine

Answer 14

Bitter taste, epistaxis

Question 15

What are contraindications to azelastine use

Answer 15

Concurrent use of alcohol or other CNS depressants

Question 16

What is the H2 receptor antagonist with the most drug interactions

Answer 16

Cimetidine