Chapter 4 Flashcards
Tissue
a group of cells that usually have a common origin in an embryo and function together to carry out specialized activities.
Histology
the science that deals with the study of tissues.
Pathologist
a physician who examines cells and tissues to help other physicians make accurate diagnoses.
Body tissues can be classified into 4 basic types based on function and structure. What are these 4 types
Epithelial tissue, Connective Tissue, Muscular tissue, Nervous Tissue
Epithelial Tissue
covers body surfaces and lines hollow organs,
body cavities, and ducts; it also forms glands. This tissue allows the
body to interact with both its internal and external environments.
Connective Tissue
protects and supports the body and its organs.
Various types of connective tissues bind organs together, store
energy reserves as fat, and help provide the body with immunity to
disease-causing organisms.
Muscular Tissue
composed of cells specialized for contraction and generation of force. In the process, muscular tissue generates
heat that warms the body.
Nervous Tissue
detects changes in a variety of conditions inside and outside the body and responds by generating electrical signals called nerve action potentials (nerve impulses) that activate muscular contractions and glandular secretions.
Cell Junctions
are contact points between the plasma membranes of tissue cells.
Five most important types of cell junctions
tight junctions, adherens junctions, desmosomes,
hemidesmosomes, and gap junctions
Tight Junctions
consist of weblike strands of transmembrane proteins that fuse together the outer surfaces of adjacent plasma membranes to seal off passageways between adjacent cells
Adherens Junctions
plaque (PLAK), a dense
layer of proteins on the inside of the plasma membrane that attaches
both to membrane proteins and to microfilaments of the cytoskeleton. Adherens junctions help epithelial
surfaces resist separation during various contractile activities.
Cadherins
Transmembrane glycoproteins that join the cell
Adhesion Belts
In epithelial cells, adherens junctions oft en form extensive
zones called adhesion belts
Desmosomes
contain plaque and have transmembrane glycoproteins (cadherins) that extend into the intercellular space between adjacent cell membranes and attach cells to one another. the plaque of desmosomes does not attach to microfilaments.
Hemidmosomes
resemble desmosomes, but they do not link adjacent cells.
Integrins
the transmembrane
glycoproteins in hemidesmosomes
Laminin
On the outside of the
plasma membrane, the integrins attach to the protein.
Gap Junctions
membrane proteins called connexins form tiny fluid-filled tunnels called connexons that connect neighboring cells.
Comparison between
Epithelial and Connective
Tissues
The first obvious difference is the number of cells in relation
to the extracellular matrix (the substance between cells). The second obvious difference is that an epithelial tissue has
no blood vessels, whereas most connective tissues have significant networks of blood vessels.
Epithelial Tissue
consists of cells arranged in continuous sheets, in either single or multiple layers. Epithelial tissue protects, secretes (mucus, hormones, and enzymes), absorbs (nutrients in the gastrointestinal tract), and excretes (various
substances in the urinary tract).
3 different Surfaces of Epithelial Cells
Apical Surface, Lateral Surface, Basal Surface
Apical Surface
faces the body surface, a body cavity, the
lumen (interior space) of an internal organ, or a tubular duct that
receives cell secretions. May contain cilia and microvili
Lateral Surface
face the adjacent cells on either side, may contain tight junctions, adherens junctions, desmosomes, and/or gap junctions.
Basal Surface
Deepest layer of cells
Basement membrane
thin extracellular layer that commonly consists of two layers, the basal lamina and reticular lamina. Attaches to and anchors the epithelium to its underlying connective tissue. Form a surface along which epithelial cells migrate during growth or wound healing, restrict passage of larger molecules between epithelium and connective tissue, and participate in filtration of blood in the kidneys.
Basal Lamina
It contains proteins such as laminin and collagen as well as glycoproteins and proteoglycans
Reticular Lamina
contains proteins such as collagen produced by connective
tissue cells called fibroblasts
Avascular
Epithelial tissue is avascular and has its own nerve supply. Relying on the
blood vessels of the adjacent connective tissue to bring nutrients and remove wastes.
Exchange of substances between an epithelial tissue
and connective tissue occurs by
Diffusion
Different roles of Epithelial Tissue
protection, filtration, secretion, absorption, and excretion.
Epithelial Tissue Divided into 2 types
Covering and
lining epithelium and Glandular epithelium.
Covering and
lining epithelium
forms the outer covering of the skin and some internal organs. It also forms the inner lining of
blood vessels, ducts, body cavities, and the interior of the respiratory,
digestive, urinary, and reproductive systems.
Glandular epithelium
makes up the secreting portion of glands such as the thyroid gland,
adrenal glands, sweat glands, and digestive glands.
Arrangement of cell layers
Simple Epithelium, Pseudostratified epithelium, Stratified epithelium
Simple Epithelium
a single layer of cells that functions in diffusion, osmosis, filtration, secretion, or absorption. Secretion
is the production and release of substances such as mucus,
sweat, or enzymes. Absorption is the intake of fluids or other
substances such as digested food from the intestinal tract.
Pseudostratified epithelium
multiple layers of cells because the cell nuclei lie at different levels and not all cells reach the apical surface; it is actually a simple epithelium because all its cells rest on the basement membrane. Cells that do extend to the apical surface may contain cilia; others (goblet cells) secrete mucus.
Stratified epithelium
consists of two or more
layers of cells that protect underlying tissues in locations where there is considerable wear and tear.
Classification of Epithelial Tissue
1) the arrangement of cells into layers and 2) the shapes of the cells
Cell Shapes
Squamous cells, . Cuboidal cells, Columnar cells, Transitional cells
Squamous cells
thin, which allows for the
rapid passage of substances through them.
Cuboidal cells
tall as they are wide and are shaped like
cubes or hexagons. They may have microvilli at their apical surface and function in either secretion or absorption.
Columnar cells
taller than they are wide, like columns, and protect underlying tissues. Their apical surfaces may have cilia or microvilli, and they oft en are specialized for secretion
and absorption.
Transitional cells
change shape, from squamous to cuboidal
and back, as organs such as the urinary bladder stretch (distend) to a larger size and then collapse to a smaller size.
Simple epithelium
A. Simple squamous epithelium
1. Endothelium (lines heart, blood vessels, lymphatic vessels)
2. Mesothelium (forms epithelial layer of serous membranes)
B. Simple cuboidal epithelium
C. Simple columnar epithelium
1. Nonciliated (lacks cilia)
2. Ciliated (contains cilia)
D. Pseudostratified columnar epithelium
1. Nonciliated (lacks cilia)
2. Ciliated (contains cilia)
Stratified epithelium
A. Stratified squamous epithelium*
1. Nonkeratinized (lacks keratin)
2. Keratinized (contains keratin)
B. Stratified cuboidal epithelium*
C. Stratified columnar epithelium*
D. Transitional epithelium or urothelium (lines most of urinary tract)
Function of Glandular Epithelium
secretion, which is accomplished by glandular cells that oft en lie in clusters deep to the covering and lining epithelium.
Gland
consists of epithelium that secretes
substances into ducts (tubes), onto a surface, or eventually into the blood in the absence of ducts.
Two type of glands
Endocrine and Exocrine
Endocrine Glands
Secretions are called hormones, enter the interstitial fluid and then diffuse into the bloodstream without flowing through
a duct.
Exocrine Glands
secrete their products into ducts that empty onto the surface of a covering and lining epithelium such as the skin surface or the lumen of a hollow organ.