Chapter 32- Neuromuscular Diseases Flashcards
Signs and symptoms of neuromuscular diseases
Exertional dyspnea
Fatigue
Orthopnea
Cor pulmonale
What are the major consequences of resp muscle weakness
Resp insufficiency and inability to clear secretions
What does orthopnea indicate
Diaphragm weakness
How can neuromuscular disease be suspected with normal pft
Repeat while patient is supine, if fev1 or fvc is 20 percent less, diaphragm weakness is present
What is diaphragm pacing
Direct stimulation of an intact phrenic nerve to contract the diaphragm
What are suggested niv settings for neuromuscular patients
Lower Epap-2-3
Higher iPap-7-15
What is critical illness myopathy
Flaccid weakness of proximal muscles making patients difficult to wean from mv
What are risk factors for developing critical illness myopathy
Corticosteroids use
Paralytics
Hyperglycaemia
Hyperthyroidism
How is critical illness myopathy prevented
Avoiding risk factors
What are 3 disorders of the neuromuscular junction
Mg
Lambert-eaten syndrome
Poisoning (botulism, tetanus)
What is mg
Intermittent muscular weakness
How can mg be differentiated from other neuromuscular disorders
Tensilion test- muscle weakness will improve when given eprophonium or neostigmine
How does mg arise
Production of antibodies against ach
Antibodies deactivate ach and block nerve transmission
Mg typically starts where
In the eyelids
What is myasthenic crisis
Respiratory failure or inability to maintain airway