Chapter 32: Medication Administration (IRAT/GRAT #2) Flashcards
___ of American adults take at least one medication.
___ take five or more.
82%
29%
_____ emergency department visits and _______ are due to adverse drug events annually
700,000
120,000
_____ is spent on extra medical costs of adverse drug events annually
$3.5 billion
At least ____ of cost of ambulatory (non-hospital) adverse drug events are estimated to be preventable.
40%
In what steps do nurses play an essential role in safe medication?
- preparation
- administration
- evaluation of medication effects
- documenting patient response to treatment
- patient teaching including side effects
- ensuring adherence to medication regimen
- evaluating the patients or caregivers ability to self-administer
What medication regulations has the most influence on the nursing practice?
your state’s Nursing Practice Act
In relation to medication regulations, be aware of
federal, state and institutional regulations
Violations of the Controlled Substances Act are punishable by
fines, imprisonment, and/or the loss of the nurse’s license
What policies should you follow for the proper storage and distribution of medication and narcotics?
your institution’s policies
Pharmacokinetics: Factors that influence absorption
- route of administration
- ability of the medication to dissolve
- blood flow to site of administration
- body surface area
- lipid solubility of medication
medications placed on mucous membranes and respiratory airways
are absorbed quickly
What form of medications are absorbed more quickly?
medications already in a liquid state are absorbed more quickly
What areas absorb more quickly?
vascular areas absorb more quickly (mucous membranes)
The majority of medications are absorbed in
the small intestine
because small intestine is highly permeable, has high blood flow, and large surface area
What type of medications can cross cell membranes easily?
highly lipid soluble medications cross cell membranes easily.
food in the stomach may also be a factor in absorption.
Pharmacokinetics: Factors that in influence distribution
- circulation
- membrane permeability
- protein binding
The effect of Circulation on distribution of medications
ex) patients with heart failure have impaired circulation, therefore slowing medication delivery
The effect of Membrane Permeability on distribution of medications
blood brain barrier allows only fat-soluble medications to pass into the brain and cerebral spinal fluid
The effect of Protein Binding on distribution of medications
the degree to which medications bind to serum proteins (albumin) affects distribution
Metabolism
failure of organs that metabolize drugs puts patients at risk for medication toxicity
(ex. liver degrades many harmful chemicals before entering the tissues, so if liver is impaired, elimination of drugs is slower, causing an accumulation of drugs and risk for toxicity.)
Excretion
-elimination of drug through lungs, liver, kidneys, bowels, and exocrine glands.
Therapeutic Effects
the expected or predicted response
Side Effects
predictable often unavoidable, r/t normal therapeutic doses
Adverse Effects
unintended, undesirable, often unpredictable. May be severe or life threatening.
What are the type of adverse effects?
- toxic effects
- idiosyncratic reactions
- allergic reactions
- anaphylactic reactions
Toxic effects
develop after prolonged intake of medication: medication accumulates in the blood r/t impaired metabolism or excretion
Idiosyncratic Reactions
reaction other than normal: over or under reacts
Allergic Reactions
allergic response develops from a repeated administration
Anaphylactic Reactions
life threatening.
characterized by sudden constriction of bronchiolar muscles, edema of the pharynx and larynx, and severe wheezing and SOB
Synergistic Effect
combined effect of two medications is greater than either one on its own: ex) alcohol and antidepressants
Polypharmacy
- when a patient takes 2 or more medications to treat the same illness
- when a patient takes 2 or more medications from the same chemical class
- when the patient uses 2 or more medications w/ the same or similar actions to treat several disorders simultaneously
- when a patient mixes herbals or nutritional supplements with medications
Polypharmacy places patients
at risk of adverse reactions and medication interactions
Many patients visit several healthcare providers all
prescribing medications for different or similar complaints
Peak
the highest level of medication concentration in the blood
Trough
the lowest level of medication concentration in the blood. Usually drawn 30 min before the time of administration.
Biological Half-Life
time it takes for the excretion process to lower the amount of unchanged medication by half
What are the effects of aging on metabolism?
- liver mass shrinks
- hepatic blood flow and enzyme activity declines
- metabolism drops to one half to two thirds the rate of young adults
- enzymes lose ability to process some drugs, thus prolonging drug half-life
Routes of Administration: Oral
slower onset of action, more prolonged effect than on parenteral.
When measuring liquid medication in a measuring cup,
measure at eye level on a hard surface
sublingual
under the tongue
buccal
in the mouth against the cheek
Parenteral
- intradermal (ID)
- subcutaneous (SQ)
- intramuscular (IM)
- intravenous (IV)