Chapter 31 HPA Flashcards
1
Q
Cosyntropin (cortroxyn)
A
- synthetic analogue of human corticotropin
- used in diagnostic testing for primary vs secondary adrenal insufficiency, congenital adrenal hyperplasia, or ovarian hyperandrogenism
2
Q
corticorelin (acthrel)
A
- recombinant ovine hormone that imitates functions of corticotropin releasing hormone
- used for diagnostic testing in Cushing syndrome (pituitary adenoma vs adrenal tumor)
3
Q
somatotropin (humatrope)
A
- biosynthetic form of naturally occurring growth hormone
- used to treat various growth hormone deficiencies in children
4
Q
mecasermin (increlex)
A
- recombinant form of IGF-1
- used to treat growth failure in children with severe IGF-1 deficiency
- may cause hypoglycemia
5
Q
octreotide (sandostatin)
A
- somatostatin analogue with greater selectivity for growth hormone vs pancreas
- used in acromegaly
- used in various neoplasm producing growth hormone
6
Q
lanreotide (somatuline depot)
A
- prolonged release analog of somatostatin
- can be administered monthly
7
Q
pegvisomant (somavert)
A
- growth hormone derivative that acts as a receptor blocker
- normalizes IGF-1 in acromegaly
- improves S/S of acromegaly, even if resistant to octreotide
8
Q
menotropins (menopur)
A
- contains FSH and LH
- refined from urine of menopausal women
9
Q
human chorionic gonadotropin (hCG, pregnyl)
A
isolated from urine of pregnant women
10
Q
choriogonadotropin alfa (ovidrel)
A
recombinant DNA form of hCG
11
Q
follitropin alfa/beta
A
recombinant FSH
12
Q
lutropin alfa
A
reconbinant LH
13
Q
leuprolide (lupron)
A
- synthetic analogues of GnRH with longer half life than natural hormone
- affects release of FSH, LH
- used for prostate, breast, uterine cancer
- used in precocious puberty, endometriosis
14
Q
ganirelix (orgalutran)
A
- competitive antagonist at GnRH receptors
- inhibits secretion of FSH, LH
- used in prevention of premature LH surge/ovulation, advanced prostate cancer
15
Q
thyrotropin (TSH, thyrogen)
A
-used to increase thyroid gland uptake of RAI
16
Q
oxytocin (pitocin)
A
- induces uterine contraction/labor
- prevents post-partum hemorrhage
- stimulates milk ejection
17
Q
vasopressin
A
- simulates V1 receptors for vasoconstriction
- stimulates V2 to increase renal actions
18
Q
desmopressin (DDAVP)
A
- long acting synthetic vasopressin analogue
- more ADH effect and less vasoconstrictive
- used in nocturnal enuresis, control bleeding, congenital or drug induced platelet defects, von Willebrand disease, hemophilia A
