Ch 32 Thyroid Flashcards
1
Q
Levothyroxine (Synthroid, T4)
A
- DOC for thyroid hormone replacement
- IV loading doses for myxedema coma
- narrow therapeutic index
- different manufacturers can have different bioavailability
2
Q
Liothyronine (T3, Cytomel)
A
-synthetic thyroid hormone
3
Q
Liotrix (T4, T3, Thyrolar)
A
synthetic thyroid hormone
4
Q
Thyroid desiccated (Armour Thyroid)
A
porcine thyroid hormone
5
Q
Methimazole (Tapazole)
A
- thioamide
- inhibits synthesis of thyroid hormone by interfering with thyroperoxidase
- concentrate in thyroid gland for long acting effect despite short half-life
- depletes T3/T4 glandular stores in 4-8 weeks to normalize circulating levels
- induce remission in Grave’s disease (12-24 month Rx)
- AE: SLE like syndrome, pruritic maculopapular rash, transient leukopenia, arthralgias, hepatitis, agranulocytosis, fever, GI, liver failure/injury
- first line agent and DOC for 1st trimester
6
Q
propylthiouracil
A
- thioamide
- inhibits synthesis of thyroid hormone by interfering with thyroperoxidase
- concentrate in thyroid gland for long acting effect despite short half-life
- depletes T3/T4 glandular stores in 4-8 weeks to normalize circulating levels
- induce remission in Grave’s disease (12-24 month Rx)
- AE: SLE like syndrome, pruritic maculopapular rash, transient leukopenia, arthralgias, hepatitis, agranulocytosis, fever, GI, liver failure/injury
7
Q
potassium iodide
A
- immediately prevents release of hormones from thyroid gland
- Tx acute thyrotoxicosis, prepare pt for thyroid surgery, inhibit hormone release after RAI, nuclear reactor accident
- AE: skin rash, salivary gland swelling, metallic taste, sore gum, GI
8
Q
RAI (sodium iodide I-131)
A
- emits B-particles to destroy thyroid tissue
- circulating thyroid hormones return to normal after several weeks
- beta blockers to manage S/S while awaiting response to RAI
- pretreat with thioamide
- absolute contraindication in gestation
