Ch 38 Cell Wall Synthesis Inhibitor

Question 1

Penicillin G/V

Answer 1

• G for syphillis

- strep, dental infections, rheumatic fever

Question 2

penicillinase resistant

Answer 2

• nafcillin has biliary excretion

- MSSA coverage but not MRSA

Question 3

extended spectrum

Answer 3

• combined with beta lactamase inhibitor

- otitis media, strep, listeria

Question 4

cephalosporin coverage

Answer 4

lose gram + and gain gram -

from 1st to 4th generation

Question 5

cephalosporin mnemonic

Answer 5

1st - "Az and Ale"
2nd- process of elimination
3rd - "3" tri, tax, taz
4th- "4" ce"four"pime instead of cefepime
5th- "tar"

Question 6

1st generation ceph indications

Answer 6

• skin infections
• MSSA
• surgical prophylaxis

Question 7

2nd generation ceph indications

Answer 7

• pelvic infection (PID)

- intraabdominal infection

Question 8

3rd generation ceph indications

Answer 8

• gyn infections
• meningitis
• CAP
• ceftriazone = biliary excretion

Question 9

4th generation ceph indication

Answer 9

pseudomonas

Question 10

5th generation ceph indications

Answer 10

MRSA

Question 11

monobactams

Answer 11

• aztreozam
• used in patients with PCN and ceph allergy
• aerobic gram (-)
• AE: thrombophlebitis

Question 12

carbapenems

Answer 12

• very broad spectrum again multi drug resistant
• cilastatin lets drug enter urine
• lowers seizure threshold
• cross sensitive with PCN

Question 13

vancomycin

Answer 13

• DOC for MRSA
• oral DOC for C. diff
• red man syndrome, ototoxicity, nephrotoxicity

Question 14

bacitracin

Answer 14

• topical ointment

- too nephrotoxic for systemic use

Question 15

fosfomycin

Answer 15

• uncomplicated UTI due to E. coli or E. faecalis

- oral single dose