Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology II > Chapter 30 Arthritis, Gout > Flashcards

Chapter 30 Arthritis, Gout Flashcards

1
Q

aspirin and other salicylates

A
  • NSAID
  • used for pain, fever, inflammation
  • inhibits COX nonspecifically in peripheral tissues and CNS
  • longer effect on TXA2 and platelet aggregation
  • prophylaxis against MI, CVA, thromboembolism
  • avoid in children (reye syndrome)
  • AE: GI bleeding, ulceration, tinnitus, hypersensitivity in asthma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

acetaminophen (tylenol)

A
  • NSAID
  • analgesic and antipyretic
  • safe for children
  • weak anti-inflammatory
  • preferred for gestational
  • AE: risk of renal insufficiency with long term use
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

acetylcysteine (sulfhydryl antidote)

A
  • extensive hepatic metabolism, toxic doses deplete hepatic glutathione which leads to APAP OD
  • antidote supplants the glutathione and inactivates toxic metabolite
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

ketorolac (toradol)

A
  • NSAID
  • analgesic, antipyretic, anti inflammatory
  • reversibly, non-selectively inhibit COX isoenzymes
  • don’t use IV more than 3-5 days, can cause GI issue
  • AE: gastric irritation, nausea, dyspepsia, PUD, hepatotoxicity, nephrotoxicity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ibuprofen, naproxen

A
  • NSAID
  • analgesic, antipyretic, anti inflammatory
  • reversibly, non-selectively inhibit COX isoenzymes
  • AE: gastric irritation, nausea, dyspepsia, PUD, hepatotoxicity, nephrotoxicity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

caldolor

A

ibuprofen injection formula

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ofirmev

A
  • IV tylenol
  • not cost effective
  • use suppository if NPO
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

celecoxib (celebrex)

A
  • NSAID
  • COX2 inhibitor
  • analgesic, antipyretic, anti inflammatory
  • no inhibition of platelet aggregation
  • AE: CV event, diarrhea, dyspepsia, ABD pain,
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

auranofin (ridaura)

A
  • DMARD (disease modifying anti-rheumatic drug)
  • slow joint erosion in RA
  • gold salt
  • benefit 3-6 months after therapy starts
  • AE: hematologic, dermatologic, GI, renal, flushing, hypotension, tachycardia, rash, stomatitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

gold sodium thiomalate (myochrysine, aurolate)

A
  • DMARD (disease modifying anti-rheumatic drug)
  • slow joint erosion in RA
  • gold salt
  • benefit 3-6 months after therapy starts
  • AE: hematologic, dermatologic, GI, renal, flushing, hypotension, tachycardia, rash, stomatitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

prednisone (deltasone)

A
  • glucocorticoid
  • DMARD
  • act more rapidly than other DMARDs
  • long term use inhibited by serious AE
  • short course therapy for initiation or flare up
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

methotrexate (rheumatrex)

A
  • single most effective DMARD available
  • benefits early as 2-3 weeks
  • folic acid supplement may reduce AE without compromising efficacy
  • AE: GI, hematologic, pulmonary, increase LFT, teratogenic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

leflunomide (arava)

A
  • DMARD
  • alternative to methotrexate for 1st line Rx
  • AE: diarrhea, reversible alopecia, increase LFT, increase hepatoxicity when combined with MTX, teratogenic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

hydroxychloroquine (plaquenil)

A
  • antimalarial and DMARD
  • up to 6 months to see benefit
  • AE: GI, blurred vision, night blindness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

etanercept (enbrel)

A
  • DMARD

- reserved for RA refractory to MTX and other DMARDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

infliximab (remicade)

A
  • DMARD

- used in crohn’s and RA

17
Q

probenecid (benemid)

A
  • uricosuric used to prevent gout in those who under excrete uric acid
  • competitively inhibits reabsorption
  • effects may be blunted by ASA
18
Q

allopurinol (zyloprim)

A
  • xanthine oxidase inhibitor
  • prevent gout attacks in those who overproduce uric acid
  • AE: not tolerate by 25% of pts, N/V, hepatitis, skin rash, hypersensitivity
19
Q

febuxostat (uloric)

A
  • xanthine oxidase inhibitor
  • used to prevent gout attacks in those who overproduce uric acid
  • daily dosing with greater efficacy
  • AE: increase LFT, nausea, arthralgias, rash
20
Q

pegloticase (krystexxa)

rasburicase (elitek)

A
  • catabolic enzyme preparation for gout
  • breakdown uric acid
  • krystexxa 30k vs elitek 4k
21
Q

indomethacin (indocin)

A
  • NSAID

- acute gout attack

22
Q

colchicine (colcrys)

A
  • acute gout attack
  • blocks urate crystal-induced inflammation
  • AE: N/V, diarrhea, ABD cramps
  • tolerance limits use
  • diarrhea is dose limiting and requires dose titration
23
Q

sulindac

A
  • NSAID

- COX 1 and 2 inhibitor

24
Q

piroxicam (feldene)

A
  • NSAID
  • treat RA and OA
  • COX 1/2 inhibitor
25
Q

nabumetone

A
  • NSAID
  • manage RA/OA
  • COX 1/2 inhibitor
26
Q

etodolac

A
  • NSAID
  • RA, OA, juvenile idiopathic arthritis
  • COX 1/2 inhibitor
27
Q

meloxicam (mobic)

A
  • NSAID
  • RA, OA, JIA
  • COX 1/2 inhibitor
28
Q

diclofenac (voltaren)

A
  • NSAID

- COX 1/2 inhibitor

29
Q

adalimumab (humira)

A
  • DMARD

- subQ injection

30
Q

anakinra (kineret)

A
  • DMARD

- subQ injection

31
Q

abatecept (orencia)

A
  • DMARD

- IV infusion or subQ

32
Q

tocilizumab (actemra)

A
  • DMARD

- IV or subQ

33
Q

certolizumab (cimzia)

34
Q

golimumab (simponi)

35
Q

penicillamine (cuprimine)

A
  • chelating agent

- wilson’s disease, severe/active RA

36
Q

sulfasalazine (azulifidine)

A
  • 5 aminosalicylic acid derivative

- RA

37
Q

rasburicase (elitek)

A
  • urate oxidase enzyme

- manage uric acid levels

Pharmacology II (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions