chapter 24 urinary Flashcards

1
Q

Excretion – the removal of waste products.
Elimination – discharge of these products to the environment.
Homeostatic regulation of blood volume and solute concentration of blood. - hormonal impact on kidney

A

function of urinary system

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2
Q

Regulating blood pressure by regulating volume and releasing EPO (blood cell formation) and renin (angiotensin aldosterone)

Regulating ion concentration especially Na+, K+, Cl-, Ca

Stabilizing pH by eliminating excess H+

Conserving valuable nutrients* due to the filtering of things from blood but the valuable items are reabsorbed, like glucose, fatty acids, vitamins

Detoxification

A

other function of kidneys

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3
Q

The corpuscle, PCT, and DCT are located in the cortex.

The loop and collecting ducts are in the medulla.

Collecting ducts merge and drain through the renal papilla in the minor calyx.

A

nephron location and blood supply

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4
Q

Each one consists of a renal corpuscle and a renal tubule.

Blood from the afferent arteriole enters the glomerulus (capillaries).

Blood leaves the glomerulus through efferent arteriole.

Filtration of the blood occurs here at the renal corpuscle.

A

nephron

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5
Q

From the corpuscle filtrate will enter the renal tubule which has three functions.

Reabsorption of useful substances.
Reabsorption of water.
Secretion of waste products.

A

nephron 2

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6
Q
renal artery --> 
segmental arteries --> 
interlobar arteries --> 
arcuate arteries --> 
cortical radiate arteries --> 
afferent arterioles --> 
glomerulus --> 
efferent arteriole --> 
peritubular capillaries --> 
venules --> 
cortical radiate veins --> 
arcuate veins -->
 interlobar veins --> 
renal vein
A

blood supply process

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7
Q

Blood hydrostatic pressure forces water and solutes across the capillary wall.

A

filtration - basic process of urine formation

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8
Q

Removal of water and useful solutes from the filtrate back to the body. This occurs by diffusion, osmosis, carrier mediated transport etc…

A

reabsorption - basic process of urine formation

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9
Q

Transport of solutes and wastes into the renal tube by diffusion, osmosis, carrier mediated transport etc…

A

secretion - basic process of urine formation

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10
Q

High pressure creates filtrate that collects in capsular space and slowly moves through the tube
The descending loop is permeable to water – water exits tube by osmosis if there is highly concentrated blood flowing through the vessel
The ascending loop is permeable to ions

A

renal corpuscle

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11
Q

During filtration the blood pressure forces out water, solutes, and other small particles.

Useful substances such as glucose, amino acids, fatty acids, vitamins, etc.. are also filtered.

Cells and large plasma proteins are not filtered

A

renal corpuscle 2

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12
Q

The PCT reabsorbs nutrients, ions, water, and protein.

The descending loop is permeable to water. The ascending loop is permeable to ions but not water.

The DCT varies in function depending on the presence of hormones such as ADH, Aldosterone, Calcitonin

A

PCT, loop, DCT

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13
Q

is the result of BHP(35) – BCOP(25) = 10 mm Hg.

Remember that everything is filtered except large proteins, and cells.

Nephrons create about 48 gallons of filtrate per day. About 99% is reabsorbed.

The rate of filtration must be constant or death may result.
Blood volume cannot be controlled.
pH cannot be controlled.
Wastes accumulate.

A

glomerular filtration

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14
Q

is an endocrine structure that secretes EPO and Renin.

A

juxtaglomerular complex

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15
Q

job is to make RBC and stimulus to release this is low oxygen levels
we make new RBC in bone marrow

A

EPO

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16
Q

release renin when system drop in pressure

A

Juxtaglomerular cells

17
Q

Filtration rate has to be consistent: if you filter too quickly, your lose fluid and BP drops
To control rate…
1. autoregulation / myogenic mechanism: if you filter too slow, the J cells dilate the afferent variable (too much blood) and constrict efferent variable (blood cant escape)
2. filter too fast, constrict afferent and dilate efferent – this decreases the amount of blood going in and the amount that can escape – drop BP
3. PSN and SSN – SSN filtration rate will go down in fight for flight, PSN – increase filtration

Hormonal mechanism is EPO and Renin

A

juxtaglomerular complex 2

18
Q

dilation and constriction of afferent and efferent arterioles by stretch receptors.

A

autoregulation

19
Q

RAA, ADH, and ANP. Drop in glomerular BP results in the release of renin from the JGC

A

hormonal

20
Q

PNS and SNS

PNS: increases filtrate system

A

autonomic regulation

21
Q

3 mechanisms to control GFR

A

autoregulation, hormonal and autonomic regulation

22
Q

angiotensinogen protein is made by liver in circulation, part of plasma proteins
Renin converts angiotensinogen to angiotensin 1
When angiotensin circulates through lungs it converts to angiotensin 2
Angiotensin 2 has 3 factors
1. make thirsty - increases pressure
2. constrict blood vessels
3. make aldosterone – helps conserve pressure then water follows and increases pressure
aldosterone comes from adrenal gland to work on DCT to get us to pull out remaining sodium in filtrate

A

GFR process

23
Q

comes from posterior pituitary - hormone works in the DCT to helps us retain fluid to increase volume and pressure*
antidiuretic so kidney retains water

A

antidiuretic (ADA)

24
Q

comes from atrium in response to high pressure and works by excreting sodium - protein that effects sodium and comes from atrium
when BP is high it exerts force on cells and causes them to release ANP (works on DCT to prevent making more sodium to decrease pressure

A

ANP

25
Q

released by JUX cells – released in response of low levels of oxygen, goes through bone marrow to stimulate RBC production

A

EPO

26
Q

The PCT reabsorbs 99% of the glucose, amino acids, and other organic compounds.

The PCT actively reabsorbs ions such as Na, K, HCO3, Mg, PO4, SO4.
CO2 is also absorbed here and has an effect on pH we will discuss later.

Reabsorption of water by osmosis. 60% of the water is reabsorbed here.

Passive reabsorption

Secretion occurs here also but is covered when we discuss DCT.

A

reabsorption and secretion at the PCT

27
Q

Remember, the descending loop is permeable to water. The ascending loop is permeable to ions.

When water leaves the descending loop the osmotic concentration rises.

When the highly concentrated fluid flows through the ascending loop ions leave by diffusion.

This helps with passive reabsorption of water

A

Nephron Loop

28
Q

Reabsorption of Na+ and Cl- occur here as well as loss of K+. Aldosterone, ANP

Ca+ regulation occurs here as well in the presence of PTH and Calcitonin.

Secretion of H+ in exchange for Na+ (next slide)

A

the DCT

29
Q

Large proteins in urine indicate glomerulus damage

blood cell shouldn’t be in urine

A

know

30
Q

Ureters are smooth muscle tubes extending from the kidney to the bladder.

Ureters enter the bladder through ureteral openings.

Transitional epithelium lining.

Peristalsis

A

ureters, bladder and urethra

31
Q

Hollow muscular organ that stores urine.

Trigone = ureteral openings and urethra.

Transitional epithelium.

Two layers of smooth muscle called the detrusor muscle

A

urinary bladder

32
Q

Extends from the bladder to the exterior of the body.

In males the urethra is 7-8 inches and divided into three segments. Prostatic, membranous, and spongy urethra.

In females the urethra is only 1-2 inches.

Urine must also pass two sphincters. Internal and external urethral sphincters.

Stratified squamous epithelium

A

urethra

33
Q

stretch of bladder is sent to spinal cord to contract and relax internal sphincter

A

micturition reflex stimulus