Chapter 22 Respiratory System Flashcards
Pulmonary ventilation
-Breathing; the movement of air in and out of the lungs
External respiration
-Gas exchange between the blood and air filled chambers of the lungs
Internal respiration
-Exchange of gases between blood and tissues
Conducting zone
- Rigid conduits for transport of air to respiratory passages (trachea, larynx, bronchi)
- Cleanses, humidifies, and warms incoming air
Respiratory zone
-Site of gas exchange (bronchioles, alveolar ducts, alveolar sacs, microscopic structures)
Vibrissae
-nose hairs
Olfactory mucosa
-contains receptors for the sense of smell
Respiratory mucosa
- pseudostratified columnar epithelia
- goblet cells: mucous
- serous cells: enzymes (lysozyme and defensins)
Goblet cells
-Mucous
Serous cells
-Enzymes (Lysozyme: antibacterial enzyme) (Defensins: Antibiotics that aid in bacterial defense)
Lysozyme
-Antibacterial enzyme
Defensins
-Antibiotics that aid in bacterial defense
Larynx
- Past the epiglottis
- Also known as the voice box
Glottis
-Opening that produces sound by its opening and closing
Trachea
-Long, flexible tube that directs air to the bronchi
Bronchi
-Main passageway into the lungs
Bronchioles
-Passageways by which air passes through the nose or mouth to the alveoli of the lungs
Alveolar sacs
-contains a collection of alveoli
Alveolar ducts
-tiny ducts that connect the respiratory bronchioles to alveolar sacs
Type I cells
-simple squamous epithelia that secrete angiotensin converting enzyme for blood pressure regulation
Type II cells
-cuboidal cells that secrete surfactant
Alveolar pores
-allow air pressure throughout the lung to be equalized if alveolar ducts collapse by disease or damage
Alveolar macrophages
-dust cells; destroy microorganisms and pathogens
Lungs
-Occupy the entire thoracic cavity except the mediastinal septum (around the heart)
Atmospheric pressure
-pressure exerted by the weight of the air in the atmosphere
Intrapulmonary pressure
-the pressure within the lungs
Intrapleural pressure
-the pressure within the pleural cavity
Boyle’s law
-If temperature is constant, the pressure of gas is inversely related to its volume
Inspiration
-The uptake of air into the lungs (quiet inspiration)
Expiration
- Passive process based on the elasticity of lungs
- Ribs relax, lungs recoil, decreasing thoracic and interpulmonary volumes
Surfactant
-Detergent-like complex of proteins and lipids produced by type II cells
Alveolar surface tension
- Molecules more attracted to one another at surfaces than to other types (liquid versus gas) creating tension
- Lining has sufactant
Lung compliance
-Lungs distensible: the amount of stretching termed compliance
Tidal volume
-Air in and out normally (500 mL)
Inspiratory reserve volume
-Air forced beyond tidal volume (2100-3200 mL)
Expiratory reserve volume
-Air forced out of lungs (1200 mL)
Residual volume
-Air left in lungs, preventing collapse
Inspiratory capacity
-Amount that can be inspired after tidal expiration (sum of tidal and inspiratory reserve volumes)
Functional residual volume
-Amount of air left in the lungs after tidal expiration (combined inspiratory and expiratory volumes)
Vital capacity
-The total amount of exchangeable air
Total lung capacity
-The sum of all capacities
Dalton’s Law of Partial Pressures
-The total pressure exerted by a mixture is the sum of the pressures exerted independently by each gas in the mixture
Henry’s Law
-In a mixture of gas, each gas will dissolve in the liquid in proportion to its partial pressure
Ventilation
-Movement of air between the environment and the lungs
Perfusion
-The process of a body delivering blood to a capillary bed
Oxyhemoglobin
-Hemoglobin-oxygen combination
Deoxyhemoglobin
-Reduced hemoglobin
Bohr effect
-Acidosis (decreases pH) weakens hemoglobin-oxygen bond, accelerating oxygen offloading (shifts the curve to the right)
Carbonic acid
-Conversion catalyzed by carbonic anhydrase in RBCs
Bicarbonate ions
-Diffuse from RBCs to plasma
Carbonic anhydrase
-Enzyme that catalyzes the conversion to carbonic acid
Chloride shift
-Chloride ions move from the plasma to RBCs to counterbalance
Haldane effect
- the less oxygen in the blood, the more the blood can carry CO2
- Allows for the formation of more bicarbonate ions
COPD
-Chronic obstructive pulmonary disease
Asthma
-chronic lung disease that inflames and narrows the airways
Tuberculosis
- infectious disease affecting the lungs
- bacterial infection (mycobacterium tuberculosis)
Lung cancer
- Squamous cell carcinoma (bronchi epithelia)
- Adenocarcinoma (peripheral lung areas)
- Small cell carcinoma (primary bronchi)
Chronic bronchitis
-Bronchial edema, chronic productive cough, bronchospasm
Emphysema
-Destruction of alveolar walls, lung fibrosis, air trapping