Chapter 22 Flashcards
Types of lipids
Triglycerides
Phospholipids
Steroids
Triglycerides
Account for 90% of total lipids in the body
attached to glycerol
<150 mg/dl
Lipoproteins
Carriers of lipid molecules
Consist of cholesterol, triglycerides, phospholipids with protein carrier (apoprotein)
Types of lipoproteins
High-density lipoprotein (HDL)
Low-density lipoprotein (LDL)
Very low-density lipoprotein (VLDL)
LDL cholesterol
transports cholesterol from liver to tissues and organs
Carries highest amount of cholesterol
bad cholesterol
Total cholesterol level
<200mg/dl
HDL level
> 45 for men
>55 for women
LDL levels
<70 w/ CV disease
CV disease risks
DIABETES
poor diet
Why Statins Should be given at Night
Liver works primarily at night to produce LDL
except Lipitor
Statin function
decrease CHD, PAD in men and women
decrease stroke and increase survival in men not women
Statin adverse effects
`minor: HA, fatigue, muscle/joint pain neuropothy, heart burn
major: severe myopothy, rhabdomyolysis
Statin considerations
check liver function tests
Acid bile resins use
reduction in LDL
Acid bile resins adverse effects
bloating and constipation
abdominal pain
Acid bile resins considerations
no not take with other drugs, especially digoxin
take w/ food
mix w/ H2O
Fibric acid agents use
lower cholesterol
usually paired with a statin
Fibric acid agents adverse effects
bleeding
cholelithasis
liver toxicity
pancreatitis
Fibric acid agents consideration
give 30 minutes before meals
Cholesterol absorption inhibitor considerations
give with a statin
Cholesterol absorption inhibitor adverse effects
hepatitis
myopathy
upper respiratory infection
