Chapter 14: trace minerals Flashcards
functions of copper
component of ceruloplasmin
coenzyme for energy metabolism, and for collagen production
increases iron absorption (fe3+ to fe 2+)
part of superoxide dismutase antioxidant enzyme system
collagen and elastin
copper recomended intake
rda for adults is 900ug/day, deficiency is rare and toxicity is not well studied (menkes, wilsons disease)
folate
is a water soluble vitamin
functions of folate
DNA synthesis, amino acid metabolism
critical for cell division of very early embryos
functions with B12 and B6 metabolism
sources of folate
fortified grains, leafy greens, legumes, seeds, liver, easily destroyed by heat and oxygen
folate recommended intake
rda 400 ug/day for adults, 600ug/day for pregnant women, UL is 1000 ug/day
folate deficiency
anemia (large cell type), smooth, red tongue, mental confusion, weakness, fatigue, irritability, headache, shortness of breath,
Folate toxicity symptoms
masks B12 deficiency symptoms, intestinal pain cramps, nausea, vomiting, liver damage,
macrocytic anemia
severe folate or vit b12 deficiency, results in enlarged rbc containing insufficient hemoglobin, shows common symptoms of anemia
folate deficiency cell division
without DNA strands break and cell division diminishes- RNA synthesis continues resulting in large cell with large nucleus
B12 sources
foods of animal origin, fortified foods
B12 deficiency
pernicious anemia
B12 rda
2.4ug/day
B12
coenzyme helps with new cell synthesis, maintains nerve cell, breaks down some fatty acids and amino acids
B12 and folate relationship
when b12 is lacking homocysteine accumlates, linked with 10-20% of cornary heart disease
high homocysteine
can cause cholesterol to change to oxidized low density lipoprotein which damages the arteries, may make blood clot more easily then it should
other trace minerals
very small quantities, human deficiency unknown, no dri value
nickel
a cofactor for enzymes
silicon and vanadium
important in bone health
cobalt
part of vitamin B12
boron
imporant in bone health, brain activity, and immunity