Chapter 13: Vitamin D Flashcards
Vitamin D
considered a hormone, synthesized at one location and acts in another location, can be synthesized through exposure to sunlight
functions of vit D
required for calcium and phosphorus absorption in the small intestine, regulates blood calcium levels, works with PTH to stimulate osteoclasts and necessary for bone calcification, linked to immune system, reproduction, and gene activity all needing more research
Vit D synthesis in the skin
7 dehydrocholesterol (precursor made in the liver from cholesterol) and UV light form previtamin D3, added heat from the body causes the formation of Vit D3(calcicole)
Vit D synthesis from the diet
consume vit D2 from plants and v3 from animals
Vit D activation
in the liver it goes through hydroxylation in the liver to form calcidiol, and then goes through hydroxylation in the kidneys to form calcitriol
Vit D DRI
Assumes no synythesis from the sun
Vit D RDA
values range from 15-20 ug/day, higher amounts in older adults due to decrease capacity to synthesize vitamin D , it also assumes the persons sun exposure is inadequate
Sources of Vitamin D
Ergocalciferol (D2)- plants, supplements
Cholecalciferol (D3)- animal foods, sun
most food naturally contain little vitamin, mostly obtained from fortified foods (milk)
Too high of Vit D consumption
can occur from vitamins, fish oil supplements, results in hypercalcimia (high blood calcium)
Not enough vit D
can occur with disease that reduce intestinal absorption of fat, rickets occuring in children and osteomalacia in older adults