Chapter 14 (The Heart) Flashcards

1
Q

Systemic Circulation

A

Vessels that carry blood away from the left side of the heart, to the tissues, and back to the right heart
Includes Arteries and Veins

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2
Q

Arteries and Veins

A

A - Carry Oxygenated blood from left ventricles
V - Carry Deoxygenated blood back to the right atrium

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3
Q

Pulminary Circulation

A

Goes from right side of heart to left side
Includes blood vessels that go:
From the right ventricle to the lungs: Pulmonary Arteries.
From the lungs to the left atrium: Pulmonary Veins.

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4
Q

Heart Position

A

Lies in the center of the thorax

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5
Q

Primary function of CVS

CVS= Cardiovascular system

A

Transport of nutrients, water, gases, wastes, and chemical signals to and from all parts of the body.

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6
Q

Is CVS a closed or open system?

A

Closed loop system

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7
Q

4 chambers of the heart

A

2 atria, 2 ventricles

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8
Q

CVS

Includes, Transport, Waste elimination

A

Heart (pump), Blood (fluid), Blood vessels including capillaries (tubes)
Transports materials throughout the body
- From external environment: nutrients, water, and gases
- Materials between cells: hormones, immune cells, antibodies
“Waste” eliminated by cells - CO2, heat, metabolic waste

Waste - nothing is really weight when thinking about mass balance and ho

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9
Q

How does blood flow?

A

Ohm’s Law
Flow = Δ Pressure / Resistance

The Physiological Equivalent:
Q = MAP/R total peripheral

R = Total resistance in the
vessels

Need to me memorized & number

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10
Q

MAP = Q x R total peripheral

A

MAP = NET driving pressure = ΔP = P1-P2
Q = flow due to central factors = (HR x SV)
R = to resistance due to peripheral factors = diameter or r4

Adjusted to maintain homeostasis

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11
Q

Q increases, R stays the same, What will happen to MAP?

A

It will increase

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12
Q

Resistance

A

inversely proportional to resistance due to resistance
Flow = 1/R
Small changes in resistance lead to big impacts for flow

increase in resistance = decreased flow

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13
Q

Resistence depends on

R=resistance
r=radius

A

Length of the tube (L) - R=L
Radius of tube - R = 1/r4
Viscosity (n) of the fluid - R=n

R increases as L and η increase, and r decreases.

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14
Q

Radius

A

Physiolgically regulated
Vasodilation - r increases, R decreases, blood flow increases
Vasoconstriction - r decreases, R increases, blood flow decreases
… Has greatest effect on resistance

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15
Q

Blood flow

A

Down a pressure gradient (ΔP) (proportional to fluid flow)
Highest pressure (aorta) to lower pressure (vena cava & pulmonary veins)

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16
Q

Driving pressure

A

Pressure of blood created when ventricles contract

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17
Q

Flow rate

A

Volume of blood that passes per unit of time

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17
Q

Dialation and pressure relationship

A

dialation increase = pressure decreases
Dialation decreases = pressure increases

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18
Q

Pressure gradient

A

Difference in pressure b/w 2 regions

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19
Q

Pressure gradient

A

Difference in pressure b/w 2 regions

20
Q

What are the 2 movements of fluid

A

Dynamic (kinetic energy) and lateral (hydrostatic pressure)

21
Q

Hydrostatic pressure

A

: pressure exerted (in all directions) by a fluid not in motion

22
Q

Look at slide 24

A

Math

23
Q

Layers of the heart

A

Endocardium (Inner) - Endothelial cells
Myocardium (middle) - Cardiac muscles
Epicardium (outer) - External membrane (also attached to pericardial sac)

24
Q

Paracardium

A

Mebranous sac encasing heart, fused to diaphram, holds paracardial fluid

25
Q

pericardial fluid

A

lubricates and allows the heart (myocardium) to operate in a friction free environment.

26
Q

Ventricular Wall Thickness

Which one and why

A

Left is thicker b/c it pumps blood to the whole body, so it need the increased pressure

27
Q

Endocariogram

A

Provides information on:
The size and shape of the heart,
Its pumping strength, and
The location and extent of any damage.
useful for assessing diseases of the heart valves and cardiac hypertrophy.

28
Q

Myocardial Muscle

A
  • Branched
  • attached by intercalated disks
  • have a single nucleus
29
Q

Action potential shape of authorythmic and contractile cells

A

authorythmic - has ine sharp point
contractile - looks like a lowercase N

30
Q

what allows the heart to squeeze the blood up?

A

the spiral muscle arrangement (produce a wringing motion)

31
Q

Desmosomes and Gap junctions

A

Both found in Cadiac muscle
D: Strong protein that surrounds sarcomeres and bind neighbouring sarcomeres.
Allow force to be transferred.
GJ: Provide electrical connection.
Electrical signals are rapidly transmitted via these protein pores providing the basis for SYNCHRONOUS CONTRACTION.
allows for rapid cell depolarization

32
Q

Cardiac muscles Structures

A

1) Single nucleus per fiber.
2) Distinctive short rectangular shape.
- Are smaller compared to skeletal muscle
3) Spontaneously Contract
- Pacemaker cells within the sinoatrial (SA) node control rate
4) Branch and join neighboring cardiac cells through intercalated disks, which are comprised of
- Desmosomes hold cells together
- Gap Junctions move ions
5) Ca2+ is sequestered in the sarcoplasmic reticulum (SR) as in skeletal muscle but SR is less voluminous.
- Cardiac muscle depends partly on extracellular Ca2+.
6) t-tubular network is more extensive than skeletal muscle
- Allows rapid, synchronous excitation-contraction coupling.
7) Large volume of mitochondria (~ 1/3rd of volume).
- This feature is due to the dependence of the heart on aerobic ATP production.

32
Q

Cardiac muscles Structures

A

1) Single nucleus per fiber.
2) Distinctive short rectangular shape.
- Are smaller compared to skeletal muscle
3) Spontaneously Contract
- Pacemaker cells within the sinoatrial (SA) node control rate
4) Branch and join neighboring cardiac cells through intercalated disks, which are comprised of
- Desmosomes hold cells together
- Gap Junctions move ions
5) Ca2+ is sequestered in the sarcoplasmic reticulum (SR) as in skeletal muscle but SR is less voluminous.
- Cardiac muscle depends partly on extracellular Ca2+.
6) t-tubular network is more extensive than skeletal muscle
- Allows rapid, synchronous excitation-contraction coupling.
7) Large volume of mitochondria (~ 1/3rd of volume).
- This feature is due to the dependence of the heart on aerobic ATP production.

33
Q

What ensures one way flow in the heart

A

The 2 sets of valves
Mitral/bicuspid valve
Tricuspid valve
Aortic semilunar valve
Pulminary semilunar valve

34
Q

how does Cardiac muscle differ from skeletal muscle?

A

1)Smaller and have a single nucleus per fiber

2)Branch and join neighboring cells through intercalated disks

3)Gap junctions

4)T-tubules are larger and branch

5)Sarcoplasmic reticulum is smaller

6)Mitochondria occupy one-third of cell volume

35
Q

What is the type of most cardiac muscle?

A

striated muscle

36
Q

Contractile cells

contain

A

have striated fibers in sarcomeres

37
Q

Authorythmic cells

A

Where signal for contraction originates
Noncontractile myocardium
Not orginized sarcomeres

38
Q

Action potential of a cardiac contractile cell

A

0- Na+ channels open
1- Na+ channels close
2- Ca2+ channels open; fast K+ channels close
3- Ca2+ channels close; slow K+ channels open
4- Resting potential

39
Q

EC coupling in cardiac muscles Steps

A

14.1 - 55-58

40
Q

What is determined by how much Ca+ binds to troponin?

A

The number of active crossbridges

40
Q

What is determined by how much Ca+ binds to troponin?

A

The number of active crossbridges

41
Q

Action potential Authorythmic cells

A
  • unstable membrane potential
  • membrane potential never rests
  • Called pacemaker potential
42
Q

Table 14.3 Comparison of Action Potentials in Cardiac and Skeletal Muscle

A

slide 68

43
Q

what causes steep depolarization in authorythmic cells?

A

Caused by Ca+ influx

44
Q

where do action potentials start in the heart

A

Pacemaker cells

45
Q

Pacemaker potential

A

When the autorythmic cells depolarize on it’s own

46
Q

Funny Na+ channels open spontaneously at

A

-60mV