Chapter 14 Lecture Flashcards

1
Q

anabolism

A

the biosynthesis of LARGER CMPDS FROM SMALLER CMPDS.
- typically REDUCTIVE (addition of electrons)
- ENERGY REQUIRED

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2
Q

catabolism

A
  • LARGER CMPDS. BROKEN DOWN into SMALLER CMPDS.
  • energy RELEASED
  • OXIDATIVE (release of electrons)
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3
Q

linear

A
  • a CONTINUOUS LINE of SERIES of RXNS
  • PRODUCT of one reaction is REACTANT in other
    ex. glycolysis
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4
Q

circular

A
  • series of rxns. where FINAL PRODUCT is the INITIAL REACTANT
    ex. Krebs cycle
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5
Q

spiral

A
  • series of REPEATED REACTIONS used to BREAK or MAKE a MOLECULE
    ex. fatty acids degradation
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6
Q

spontaneous or favorable reaction

A
  • CONTINUES ITSELF ONCE STARTED
  • energy is RELEASED (-deltaG)
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7
Q

nonspontaneous or unfavorable reaction

A
  • WILL NOT TAKE PLACE UNLESS IT IS COUPLED !!
  • with a SPONTANEOUS OR FAVORABLE RXN.
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8
Q

coupled reaction

A

paired nonspon. + spon. rxn

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9
Q

in a coupled rxn…?

A
  • spontaneous rxn PROVIDES ENERGY NEEDED by a nonspontaneous or favorable one
    ex. forming ATP (+deltaG)
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10
Q

catabolism and anabolism linked through?

A
  • through ATP and HYDROLYSIS
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11
Q

in ATP:

A
  • the energy is then STORED into a PHOSPHODIESTER BOND - HIGH ENERGY BOND
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12
Q

catabolism always begins with?

A

digestion

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13
Q

starch digestion

A
  • begins within the MOUTH
  • starch amylase CATALYZES the HYDROLYSIS of alpha (1-4) GLYCOSIDIC BONDS
  • other remaining starch is broken in the SMALL INTEST.
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14
Q

triglyceride digestion

A
  • needs the EMULSFICATION OF TRIGLYCERIDES by BILE SALTS
  • often broken down in the SMALL INTEST.
  • FATTY ACIDS are RELEASED
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15
Q

protein digestion

A
  • begins in the STOMACH
  • the enzyme PEPSIN CATALYZES HYDROLYSIS of PEPTIDE BONDS
  • SMALL INTEST- rest of peptide bonds
  • AMINO ACIDS RELEASED, then absorbed into blood
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16
Q

glycolysis

A

the breakdown of GLUCOSE into PYRUVATE
- is a 10 STEP LINEAR PATHWAY/UNIVERSAL PATHWAY
- occurs in CELL CYTOPLASM
1 glucose — 2 pyruvates + 2 ATP + 2 NADH

17
Q

glycolysis steps 1-5

A
  • known as the PREP or INVESTMENT PHASE
  • because of the INPUT OF ENERGY
  • will require 2 ATP
    based with the conversion of 1 GLUCOSE into 2 GLYCERALDEHYDE 3-PHOSPHATES
18
Q

glycolysis steps 6-10

A
  • called the PAY-OFF PHASE
  • production of FOUR ATP and 2 NADH
  • production of 2 PYRUVATE
19
Q

glycolysis step 3

A
  • the MAIN REG. STEP
  • ATP becomes a NEG. EFFECTOR for PFK
    because of cell energy “rich” - GLYCOLYSIS TURNED OFF
  • ADP becomes a POST. EFFECTOR
    because of cell energy “poor” - GLYCOLYSIS TURNED ON
20
Q

what does anaerobic conditions lead to?

A

LACTATE FORMATION
- due to vigorous exercise

21
Q

what happens to lactate produced in the muscles?

A
  • beings with the CORI CYCLE
    1. LACTATE goes into BLOOD and sent to LIVER
    2. LIVER: LACTATE - PYRUVATE
    3. PYRUVATE goes through GLUCONEOGENSIS
    4. GLUCOSE goes into BLOOD and MUSCLES
    5. GLUCOSE - PYRUVATE *glycolysis
    6. PYRUVATE - LACTATE
    repeat
22
Q

what does aerobic condtions lead to?

A

acetyl-CoA formation
- PYRUVATE converted into acetyl-CoA

23
Q

gluconeogenesis

A

the making of GLUCOSE from LACTATE or some AMINO ACIDS
- occurs in LIVER and DURING EXERCISE
- also occurs during FASTING or EARLY STAGES of STARVATION
- *glucose - brain fuel

24
Q

what happens to acetyl-Coa once formed?

A

enters the CITRIC ACID CYCLE/TRICARBOXYLIC ACID CYCLE/KREBS CYCLE
- 8 step circular path
- C ATOMS in acetyl group - FULLY OXIDIZED