Chapter 14 Flashcards
as proto-oncogenes normally promote cell division or cell survival
oncogenes
what mutations are usually a gain-of-function and dominant
oncogene
genes normally arrest cell division
tumor suppressors
What gene mutation is usually a loss of function and recessive
tumor suppressor
antigens, Jean rearrangements are what markers
tissue specific markers
trans locations, point mutations, polymorphisms in tumor suppressor or oncogenes are what markers
disease-specific markers
What gene encodes one of a family of human epidermal growth factor receptors
HER2/neu
What gene is frequently Amplified in breast cancer cells, resulting in increased amounts of her2 cells
her2 Neu
what expressing tumor is sensitive to herceptin
her2
what oncogene encodes another of the same family of epidermal growth factor receptors
EGFR
tumors with activating mutations in egfr are sensitive to
tyrosine kinase inhibitors
egfr gene mutations are detected by
sscp, SSP PCR, or direct sequencing
what oncogene encodes a key component of cell signaling in that is the most common onco mutation in cancer
kras
kras mutations are detected by
sscp and direct sequencing
what tumor suppressor Gene encodes a transcription Factor
TP53
inherited tumor suppressor gene mutations are
recessive
tumor suppressor gene mutations are
dominant with respect to increased risk of malignancy
exposes the recessive mutant allele in a hemizygous state
loss of heterozygosity
what relates to the rwo hit hypothesis
loss of heterozygosity
what are the mutations for brca1
187 / 185 d e l a g, 5382 i n s c
what is the mutation for brca2
6174 del T
what tumor suppressor genes encode proteins that participate in DNA repair
brca1 and brca2
what are short tandem repeats that are sensitive to errors during DNA replication
microsatellite
the production of new alleles from unrepaired replication errors
microsatellite instability
normal events that occur in lymphocytes
Gene rearrangements
what are the four T-cell receptor genes
Alpha, Beta, gamma,…
detected with higher sensitivity using PCR
trans locations
may be used to quantify tumor load during patient monitoring
qpcr
t (14 18)
DLBCL, Follicular
found in 90% of follicular lymphoma cases and 20 to 30% of large cell lymphoma
t 14;18
with translocation, the b-cell Leukemia and Lymphoma becl2 Gene is moved from what chromosome to what chromosome
chromosome 18 to chromosome 14
what translocation forms of Tamara Jean between the breakpoint cluster region gene on the chromosome 22 and the Abelson leukemia virus gene on chromosome 9
t 9,22
CML, ALL
t 9,22
what translocated chromosome is the Philadelphia chromosome
t 9,22
IG and TCR Gene rearrangements are tissue specific markers for certain
lymphoma and Leukemia
