Chapter 14

Question 1

as proto-oncogenes normally promote cell division or cell survival

Answer 1

oncogenes

Question 2

what mutations are usually a gain-of-function and dominant

Answer 2

oncogene

Question 3

genes normally arrest cell division

Answer 3

tumor suppressors

Question 4

What gene mutation is usually a loss of function and recessive

Answer 4

tumor suppressor

Question 5

antigens, Jean rearrangements are what markers

Answer 5

tissue specific markers

Question 6

trans locations, point mutations, polymorphisms in tumor suppressor or oncogenes are what markers

Answer 6

disease-specific markers

Question 7

What gene encodes one of a family of human epidermal growth factor receptors

Answer 7

HER2/neu

Question 8

What gene is frequently Amplified in breast cancer cells, resulting in increased amounts of her2 cells

Answer 8

her2 Neu

Question 9

what expressing tumor is sensitive to herceptin

Answer 9

her2

Question 10

what oncogene encodes another of the same family of epidermal growth factor receptors

Answer 10

EGFR

Question 11

tumors with activating mutations in egfr are sensitive to

Answer 11

tyrosine kinase inhibitors

Question 12

egfr gene mutations are detected by

Answer 12

sscp, SSP PCR, or direct sequencing

Question 13

what oncogene encodes a key component of cell signaling in that is the most common onco mutation in cancer

Answer 13

kras

Question 14

kras mutations are detected by

Answer 14

sscp and direct sequencing

Question 15

what tumor suppressor Gene encodes a transcription Factor

Answer 15

TP53

Question 16

inherited tumor suppressor gene mutations are

Answer 16

recessive

Question 17

tumor suppressor gene mutations are

Answer 17

dominant with respect to increased risk of malignancy

Question 18

exposes the recessive mutant allele in a hemizygous state

Answer 18

loss of heterozygosity

Question 19

what relates to the rwo hit hypothesis

Answer 19

loss of heterozygosity

Question 20

what are the mutations for brca1

Answer 20

187 / 185 d e l a g, 5382 i n s c

Question 21

what is the mutation for brca2

Answer 21

6174 del T

Question 22

what tumor suppressor genes encode proteins that participate in DNA repair

Answer 22

brca1 and brca2

Question 23

what are short tandem repeats that are sensitive to errors during DNA replication

Answer 23

microsatellite

Question 24

the production of new alleles from unrepaired replication errors

Answer 24

microsatellite instability

Question 25

normal events that occur in lymphocytes

Answer 25

Gene rearrangements

Question 26

what are the four T-cell receptor genes

Answer 26

Alpha, Beta, gamma,…

Question 27

detected with higher sensitivity using PCR

Answer 27

trans locations

Question 28

may be used to quantify tumor load during patient monitoring

Answer 28

qpcr

Question 29

t (14 18)

Answer 29

DLBCL, Follicular

Question 30

found in 90% of follicular lymphoma cases and 20 to 30% of large cell lymphoma

Answer 30

t 14;18

Question 31

with translocation, the b-cell Leukemia and Lymphoma becl2 Gene is moved from what chromosome to what chromosome

Answer 31

chromosome 18 to chromosome 14

Question 32

what translocation forms of Tamara Jean between the breakpoint cluster region gene on the chromosome 22 and the Abelson leukemia virus gene on chromosome 9

Answer 32

t 9,22

Question 33

CML, ALL

Answer 33

t 9,22

Question 34

what translocated chromosome is the Philadelphia chromosome

Answer 34

t 9,22

Question 35

IG and TCR Gene rearrangements are tissue specific markers for certain

Answer 35

lymphoma and Leukemia