Chapter 12: Cell Cycle Flashcards
Types of cell division
Mitosis and meiosis
Mitosis
Division of somatic (non-reproductive) cells
Meiosis
Division of gametes (reproductive cells)
Genome
All the DNA inside of a cell
(One or many DNA molecules)
Chromosome
Package of DNA molecules in a cell
Chromatin
Complex of DNA and proteins that condenses during cell division
Diploid
2 sets of chromosomes (2n)
Haploid
One set of chromosomes (n)
Somatic cells
Non-reproductive cells
Gametes
Reproductive cells (sperm and ovum/eggs)
Sister chromatids
Joined copies of an original chromosome
Centromere
Narrow “waist” of a duplicated chromosome
Cytokinesis
Division of the cytoplasm
Interphase
Period of cell growth and chromosome duplication before mitosis
G1 phase
Gap 1 (Cell growth, protein and organelle production)
S phase
Synthesis (chromosome duplication/ DNA replication)
G2 phase
Gap 2 (cell growth and preparation for mitosis)
Mitotic spindle
Microtubule structure that controls chromosome movement during mitosis
Centrosome
Microtubule-organizing center
Kinetochore
Protein complex associated with the centromere
Metaphase plate
Imaginary plane midway between the spindle’s two poles
Prophase
Chromatin condenses, nucleus disappears,
spindles form
Metaphase
Chromosomes line up on the metaphase plate, centromeres on opposite poles
Anaphase
Sister chromatids separate, chromosomes are pulled to poles
Telophase & Cytokinesis
Chromosomes condense, nucleus reforms, cytoplasm pinches
Cleavage
Process of dividing the cytoplasm
Cell plate
A cell wall formed between two duplicated plant cells
Binary fission
Prokaryotic cell division
Origin of replication
Beginning of chromosome replication during binary fission
Cell cycle control system
Regulatory clock with checkpoints that controls the cell cycle
Checkpoints
Points in which the cell cycle stops until a go-ahead signal is given
Cyclin
Regulatory protein that fluctuates in concentration throughout the cycle
Cyclin-dependent kinase (CDK)
Regulatory protein that binds with cyclin and who’s activity rises with its concentration
Maturation-promoting factor (MPF)
Cyclin-CDK complex that triggers a cell’s passage past the G2 checkpoint into the M phase
G0 phase
Non-dividing state reached when the go-ahead signal is not received by a cell
Growth factors
Proteins released by certain cells to stimulate other cells to divide
Density-dependent inhibition
Crowded cells stop dividing
Anchorage dependence
Cells must be attached to a substratum in order to divide
Transformation
Acquiring the ability to divide indefinitely
Tumor
Mass of abnormal cells within otherwise normal tissue
Benign tumor
Abnormal cells remain only at original site
Malignant tumor
Abnormal cells that invade surrounding tissues
Metastasize
When cancer cells spread to other parts of the body forming additional tumors