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IHP 1001 > Ch.6 Connective Tissue > Flashcards

Ch.6 Connective Tissue Flashcards

1
Q

Comprises a diverse group of cells within a tissue-specific extracellular matrix

A

connecitve tissue

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2
Q

?

A

Connective Tissue

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3
Q

Connecitve tissue consist of cells within?

A

Cell within the ECM

Contains protein fibers & ground substance

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4
Q

3 classifications of connecitve tissue?

A
  1. Embryonic
  2. Connecitve tissue proper
  3. Specialized
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5
Q
  • Mesenchyme
  • Mucous Connective Tissue
A

Embryoni connecitve tissue

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6
Q
  • Loose Connective Tissue
  • Dense Connective Tissue
A

Connective tissue proper

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7
Q
  • Cartilage
  • Bone
  • Adipose Tissue
  • Blood
  • Hemopoietic Tissue
  • Lymphatic Tissue
A

specialized connecitve tissue

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8
Q
  • Derived from the mesoderm
  • Found in the embryo
  • Extracellular space occupied by viscous grpup substance with limited collagen fibers
A

Mesenchyme

E, con, tissue

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9
Q
  • Present in umbilical cord
  • Ground substance known as wharton’s jelly
A

Mucous Connective tissue

E, con, tissue

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10
Q

2 types of conencitve tissue proper?

A
  1. Loose connecitve tissue (areolar)
  2. Dense Connecitve tissue (regular & iregular
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11
Q

?

A

Loose Connective tissue

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12
Q
  • Thin, relatively sparse collagen fibers
  • Abundant ground substance
  • Primarily located beneath epithelia
A

Loose connective tissue

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13
Q

where do sites of inflammation and swelling occur? significant swelling

A

Loose connective tissue

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14
Q
  • Contains mostly collagen fibers
  • Cells are sparse and * typically fibroblasts
  • Very little ground substance
  • Strong tissue, allows organs to resist excessive stretching and distention.
A

Dense connective tissue

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15
Q

Example of Dense connecitve tissue?

A

Reticular layer of dermis

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16
Q

Dense connecitve tissue

Ordered and densely packed arrays ____ with cells (tendioncytes) aligned between fiber bundles.

A

collagen fibers

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17
Q

Dense connective tissue is a functional component of what? (4)

A
  1. Tendons
  2. Ligaments
  3. Aponeuroses
  4. PDL
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18
Q

3 types of connecitve tissue fibers?

A
  1. Collagen
  2. Reticular
  3. Elastic
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19
Q
  • Most abudant component of connecitve tissye
  • Flexible high tensile strength
A

Collagen Fibers

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20
Q

What subunits make up collagen fibers?

A

collgen fibrils
* 68nm banding patter
* Gap

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21
Q

explain structure of collagen

A
  • Triple helic of 3 polypeptide chains
22
Q

What is the main collagen in the body?

A

Type I

30 diffrent kinds

23
Q

In collagen biosyntheisis, what occurs

A

Proline and lysine hydroxylation

24
Q

What is the cofactor required for hydroxylation of prolien and lysine for collagen biosynthesis

A

Ascorbic acid (VitC)

25
Q

Where are procollagen molecules formed?

A

Within fibroblasts

26
Q

Procollagen fibers are ceaved into ____ which are assemebled into larger collegen fiber outside in the ECM

A

Procollagen cleaved into fibrils

28
Q

Collagenopathies

  • Type I collagen
  • Brittle bones, abnormal teeth, thin skin, weak tendons, progressive hearing loss
A

Osteogenisis imperfecta

29
Q

Collagenopathies

  • Type 3 Collagen
  • Hypermobility of all joints, finger joint deformities
A

Ehlers-Danlos, type 3

30
Q

Collagenopathies

  • Type 3 collagen
  • Pale, translucent, thin skin
  • Also known as vascular ____
A

Ehlers-Danlos syndrome type 4

31
Q

Type V collagenopathy

A

Classical Ehlers-Danlos

32
Q
  • Provide a supporting framework for the cellular components of tissues and organs
  • Composed of Type III collagen
  • Named for their mesh-like arrangement
A

Reticular FIbers

33
Q

What type of connecitve tissue fibers a re prominantn in the initial stages of wound healing and scar formation?

A

Reticular fibers

34
Q

What connective tissue fiber?

Abundant in lymphatic tissues

A

Reticular Fibers

35
Q
  • Allow tissues to respond to stretch and distension
  • Thinner than collagen fibers and 1000x more flexible then collagen
  • Arranged in a 3D network cross linked elastin molecules assc. Network of fibrillin microfibrils.
A

Elastic fibers

36
Q

What 4 cells produce elastic fibers?

A
  1. Fibroblasts
  2. Chondrocytes
  3. Endothelial cells
  4. Smooth muscle cells
37
Q

What is responsisble for eslatic property of elastic fibers?

A

Polypetide makeup resulting in random coiling, hydrophobic alternate with hydrophillic

38
Q

The unique amino acids desmosine and isodesmosine are responsible for what in elastic fibers?

A

Covalent boding of elastin molecules to others

39
Q

which fibers contain NO Hydroxylysine?

A

Elastic fibers

40
Q
  • Mutated elastin formsthinner elastic fibers and disorganized elastic lamellae in the wall of the ascending aorta
  • Results in increased production of smooth muscle in aorta that causes stenosis of the artery
A

Supravascular aortic stenosis (SVAS)

41
Q
  • Characterized by wrinkled, redundant, sagging inelastic skin
  • Defective dermal elastic fiber synthesis
A

Cutis Laxa

42
Q

What kind of cells?

  • Fibroblasts and Myofibroblasts
  • Macrophages
  • Adipocytes
  • Mast cells
  • Adult stem cells
A

Resident Connecitve tissue cells

43
Q

What kind of cells?

  • Lymphocytes
  • Plasma Cells
  • Neutrophils
  • Eosinophils
  • Basophils
  • Monocytes
A

Wandering transient connecitve tissue cells

44
Q
  • Synthesize of collagen, elastic and reticular fibers
  • Produce the complex carbohydrates of ground substance
A

Fibroblasts and Myofibroblasts

Residents

45
Q

What cells similar to fibroblast are involved in wound healing by contracting edges of the wound?

A

Myofibroblasts

Resudent

46
Q
  • Palmar fibromatosis
  • Characterized by the thickening of the palmar aponeurosis
  • Increase flexion of the 4th and 5th digits of the hand
A

Dupartrens disease

do pardon my languange.. LOL

47
Q
  • Phagocytic cells derived from monocytes
  • **APCs **due to the presence of MHC II) molecules on their cell membrane
  • Promote inflammation and apotosis
A

Macrophages

Resident

48
Q

Macrophages can from ____ cells, large cells 100 macrophages fused

A

Langerhan Cells

49
Q
  • Key role in inflammation (degranulates cell)
  • Allergy and anaphylaxis
  • Important for wound healing because theystimulate angiogenesis
A

Mast Cells

Resident

50
Q

Connective tissue cell which is specialized forstorage of fat and production of hormones

A

Adipocytes

Resident

51
Q

resident in niches, dif to distinguish

A

Adult stem cells

Resident

IHP 1001 (18 decks)

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