CH 9 afd avd apd

Question 1

CH 9 afd avd apd

antifungal drugs

Answer 1

• often toxic to the host
• fungal detoxification systems inactive drug

-target cell walls (chitin) and membrane sterols–bind to cell membrane and decrease fluidity, block membrane sterol syn., interact with chitin synthase

Question 2

CH 9 afd avd apd

Fungal Infections

Answer 2

• superficial (tpical) mycoses–athelete’s foot, candidiasis
• subcutaneous (just under skin) mycoses–sporotrichiosis, rose-handler’s disease

-systemic (spreads throughout body) mycoses–often initiate in the lungs, frequently opportunistic infections

Question 3

CH 9 afd avd apd

antiviral drugs (AVD)

Answer 3

• Disrupt critical stages of viral life cycle
• block syn. of viral-specific nucleic acids

-difficult to use drug therapy since viruses use host’s cell machinery

Question 4

CH 9 afd avd apd

AVD-Acyclovir

Answer 4

targets viral DNA polymerase, high selective toxicity, herpes, chicken pox, shingles

Question 5

CH 9 afd avd apd

AVD-Vidarabine

Answer 5

• targets viral DNA polymerase

- herpes, chicken pox, shingles

Question 6

CH 9 afd avd apd

AVD-Amantadine and rimatadine

Answer 6

• Influenza A
• Blocks uptake of virus

-Parkinson’s disease

Question 7

CH 9 afd avd apd

AVD-Tamiflu and Relenza

Answer 7

Block release of virus

Question 8

CH 9 afd avd apd

AVD-Cidofovar

Answer 8

Broad-spectrum antiviralBlocks assembly of viruses

Question 9

CH 9 afd avd apd

AVD- Azidothymine (AZT)

Answer 9

Targets reverse transcriptase

Question 10

CH 9 afd avd apd

AVD-HIV drugs

Answer 10

• nucleoside reverse transcriptase inhibitors
• non-nucleoside RT inhibitors
• protease inhibitors–block assembly
• fusion inhibitors–block entry (only works on virus with a envelope)

Question 11

CH 9 afd avd apd

AVD-Viral resistance

Answer 11

• viruses can develop resistance to AVD

- H1N1 resistant to Tamiflu

Question 12

CH 9 afd avd apd

Antiprotozoan Drugs (APD)

Answer 12

-Mechanism of action for most drugs in not well understood–target NA, inteference with ETC, block RNA function, interfere with metabolic pathways-often have significant side effects, since they are eukaryotic the drugs affect humans as well, must find drugs specific to protozoan

Question 13

CH 9 afd avd apd

APD-Quinine drugs

Answer 13

• Chloroquine, qualaquin

- treatment of malaria

Question 14

CH 9 afd avd apd

APD-Artemisinin

Answer 14

-sweet wormwood

Question 15

CH 9 afd avd apd

APD-Metronidazole

Answer 15

treatment of entamoeba infections

Question 16

CH 9 afd avd apd

APD-Aminoglycosides

Answer 16

interfere with RNA function

Question 17

CH 9 afd avd apd

APD-Atovaquone

Answer 17

• Blocks ETC
• Toxoplasmosis

-Penumocystis pneumonia