Ch. 12 Flashcards
Types of neuroglia aka glial cells (found in CNS):
Bank: Microglia, Ependymal cells, Oligodendrocytes, Schwann Cells, Astrocytes, Satellite Cells
Description:
- Star-shaped cells with many processes
- Metabolize NT’s, maintain [K+] balance for CNS neurons
- Help form the blood-brain barrier (BBB)
- Serve as link between neurons & blood vessels
Nutshell: Maintains environemnt for neurons, which involves balancing POTASSIUM
Astrocytes
_______ = two or more graded potentials added together creates a greater change in membrane potential
Summation
Types of Neurotransmitters associated with CNS & PNS:
Acetylcholine is the most ______ of the neurotransmitters. It exists in both the somatic and autonomic nervous systems. It’s also excitatory (i.e. moves muscles) and inhibitory (i.e. slows heart rate)
versatile
Graded potential is
- Generated on _______ (axons/membrane of dendrites and cell body)
- Remains localized; _____ (short/long)-distance communication only
membrane of dendrites and cell body
short
Quiz: Which items fit “Graded Potential” vs “Action Potential”
____________ - small deviation from RMP caused by a certain stimulus
_______________ GP – inner membrane more negatively charged than normal RMP
_______________ GP – inner membrane less negatively charged than normal RMP
Graded Potential
Hyperpolarized
Depolarized
NOTE: Occurs due to the opening/closing of mechanically or chemically gated channels (not voltage gated)
When ions move thru these gated channels, the membrane either depolarizes OR hyperpolarizes (relative to RMP); depends on ion charge & flow direction
Faulty neurotransmitters are treated in 2 ways:
1) With drugs that _____ a NT
2) Drugs that ______ a transmission
mimic
block
Types of Neurotransmitters associated with CNS & PNS:
_____ Acids
• Excitatory CNS: Glutamate & Aspartate
• Inhibitory CNS: GABA (brain) & Glycine (spinal cord)
Amino
Types of Ion Channels: Chemically-Gated, Voltage-Gated, Mechanically-Gated, Leak Channels
- Not gated
- Randomly Open/Close
- Membrane more permeable to K+ than Na+
- More K+ leak channels and are leakier than sodium
- Found in nearly all areas & types of neurons
Leak Channels
Nervous system serves 3 basic functions that relate to maintenance of an internal balance called ___________
What are those 3?
homeostasis
- Sensing changes, both inside & outside the body (sensory function)
- Interpreting these changes (integrative function)
- Reacting to these changes by causing muscle contractions or glandular secretions (motor function)
Neurotransmitters are _____ (slowly/quickly) removed from the synaptic cleft by:
- ______ out of (away from) the synaptic cleft
- Enzymatic degradation (e.g. acetylcholinesterase)
- Uptake into cells – ______ transported back into neurons (reuptake) or into neuroglia (uptake)
quickly
- Diffusion
- actively
Branch of medical science that deals with nervous system is ___
neurology
Types of Ion Channels: Chemically-Gated, Voltage-Gated, Mechanically-Gated, Leak Channels
- Gate opens in response to neurotransmitters, hormones, and some ions
- • Found in dendrites of some sensory (pain) neurons, interneurons, & motor neurons
Chemically-Gated
What are nerve cells called?
Neurons
Other factors that can modify of membrane potential:
- Increased excitability - reduce the threshold; easier to depolarize membrane
- Alkalosis (pH > 7.45) - lightheadedness, tingling, numbness spasms, etc.
- Caffeine & nicotine
- Decreased excitability – increases threshold; more difficult to depolarize
- Acidosis (pH < 7.35) - weakness, lethargy, coma
- Hypnotics, tranquilizers, anesthetics
just look at this a few times
The PNS is divided into 3 “subdivisions”:
The _____ nervous system (SNS) is voluntary. It’s basically your muscles.
- Sensory (afferent) neurons conduct impulses from cutaneous & special sensory receptors to the CNS
- Motor (efferent) neurons send impulses from CNS to __________
Somatic
skeletal muscles
Saltatory Conduction:
• Myelin sheath = electrical insulator; blocks membrane depolarization
• Nodes of Ranvier = contains many voltagegated channels (e.g. Na+)
• Membrane depolarizes/repolarizes very _______ (slowly/quickly) at nodes
• Stops at myelin sheath
• Nerve impulse “leaps” from node to node; travels very FAST
• Also uses ______ (less/more) ATP, since only small portions of the membrane gets depolarized
Quickly
less
The word _____ means = the capability to change based on experience.
Repeat to yourself: Learning new things means making new connections! Expending the dendrites to connect to other neurons (and using your neurons!). i.e, repitition is the best way to learn).
Plasticity
Repeat to yourself: Learning new things means making new connections! Expending the dendrites to connect to other neurons (and using your neurons!). i.e, repitition is the best way to learn).
In the CNS, there is no connective tissue between nerve fiber bundles; therefore, bundle of nerve fibers (axons) are called a _____ instead of a nerve.
tract
Two basic types of synapses:
- Electrical synapse - found in smooth muscle, cardiac muscle, CNS (between neurons)
- _____ (one-way/two-way) communication between cells:
- • Ionic current spreads directly from cell to cell thru ____ junctions
- • Electrical synapses are ____(faster/slower) than chemical synapses
- • Quickly coordinates (synchronizes) activity of a group of
- neurons or muscle fibers (e.g. in heart, bladder, etc.)
two-way
gap junctions
faster
Myelination ________(decreases/increases) from birth to maturity (e.g. better coordination with time)
increases
Excitatory & Inhibitory Postsynaptic Potential:
Excitatory NT - __________ (hyperolarizes/depolarizes) the postsynaptic neuron membrane
- Inner membrane less negative; Cations IN or anions OUT
- Generates _______ (excitatory/inhibitory) postsynaptic potential (EPSP) – closer to threshold potential
- A single EPSP is not enough to start a nerve impulse. However, it is more excitable (closer to its threshold). The next EPSP may be enough to start a nerve impulse (summation).
depolarizes
excitatory
A bundle of nerve fibers in the PNS is called a nerve.
A bunde in the CNS is called a tract because it doesn’t have __________ surrounding it
nerve
connective tissue
Which cell produces the lipids and mylinates the axon?
Schwann cell
Node of __________ = Gaps in the myelin sheath; neurofibral nodes
Ranvier
Types of neurons based on transmission:
Bank: Presynaptic neuron, Postsynaptic neuron
_________________ - Sends the signal toward synapse
_________________- Receives the signal and carries message away from synapse
Prestsynaptic neuron
Postsynaptic neuron
- Chemical synapse (“slower”) - e.g. neuromuscular junction
________ (two-way/one-way) transfer of information (presynaptic to postsynaptic neuron or effector)
___________ neuron has end bulbs to release neurotransmitter
___________ neuron has receptor to recognize neurotransmitter
____________ - gap between pre-postsynaptic neurons
Bank: Postsynaptic, Presynaptic, Synaptic cleft
one-way
Presynaptic
Postsynaptic
Synaptic cleft
___________ (association neurons)
Connects sensory & motor neurons inside CNS
Most are multipolar
Interneurons
Review this “nuclei in the brain” image several times to get familiar with it
Regeneration of Nervous Tissue:
In CNS, injury ____ (can/can’t) be repaired. Learning DOES frequently stimulate production of NEW neurons in the hippocampus of the brain; but no repair of injured neurons.
Example: A spinal cord injury makes you paralyzed for good!
can’t
Durring the after-Hyperpolarizing Phase, the voltage-gated K+ channels close and RMP (resting memberate potential) returns to -70 mV with help of Na+/K+ pump.
^this pump is slowly letting # sodium out, and # potassium in until it polarizes down to -70 mV
3 sodium out, 2 potassium in
This is a ______ neuron.
It has # axon and many dendrites.
It comes in the form of both Motor Neurons & ____neurons. Located in PNS & CNS
Multipolar
1
Inter-neurons
What autoimmune disease where our body destroys our own mylin sheath in the CNS.
Caused nerve impulses to short-circut.
Multiple Sclerosis (MS)
Types of neuroglia aka glial cells (found in CNS):
Bank: Microglia, Ependymal cells, Oligodendrocytes, Schwann Cells, Astrocytes, Satellite Cells
Description:
- Looks like small astrocytes
- Form a network around axons in CNS,
- Produce the lipoprotein myelin for support
Oligodendrocytes
What is Myelination?
The process of forming a myelin sheath around a nerve to allow nerve impulses to move more quickly.
Parts of a neuron:
What is this?
Nerve fiber that conduct impulses away from cell body to another neuron OR to an effector (e.g. muscle or gland) Long, thin, cylindrical projection that may be short (mm CNS) or long (meter PNS); Has synaptic end bulbs located at terminal end; Can be myelinated.
Axon
________ - functional junction between neurons OR between a neuron & an effector (muscle or gland)
Synapse
NOTE: This is when the signal finally gets down the axon
Types of neuroglia aka glial cells (found in CNS):
Bank: Microglia, Ependymal cells, Oligodendrocytes, Schwann Cells, Astrocytes, Satellite Cells
Description:
- Phagocytic; Clean-up & protective
Microglia
Two types of neuroglial cells that myelinate neuronal axons:
_____ is in the CNS.
- Forms myelin sheath on more than one axon;
- Non-regenerative
- Myelinated (_____ matter) vs. Unmyelinated (____ matter)
Oligodendrocyte
white, grey
This is a ______ neuron.
It has # axon and # dendrites.
These are rare ________ (specialized / generalized) sensory neurons. (e.g. olfaction, seeing, & hearing)
Bipolar
1 axon, 1 (main) dendrite
specialized
The endoneurium covers the ______
axons
Excitatory & Inhibitory Postsynaptic Potential:
Inhibitory NT - ___________ (hyperolarizes/depolarizes) the postsynaptic neuron membrane
- Inner membrane more negative; Anions IN or cations OUT
- Generates ______ (excitatory/inhibitory) postsynaptic potential (IPSP) – further from threshold potential
hyperolarizes
inhibitory
review this overview of how signals transfer through a synapse