CFTR protein- lqc 6b

Question 1

What type of protein is the CFTR protein?

Answer 1

channel protein

Question 2

Where is the CFTR protein found in the human body?

Answer 2

In the (apical) membrane of mucus producing cells/epithelial cells of respiratory/digestive/reproductive systems

Question 3

What is the role of the CFTR protein?

Answer 3

Responsible for transporting chloride ions (Cl-) through cell membranes

Question 4

what is a gene mutation in the CF

Answer 4

A gene mutation in the CF gene is a change in the base sequence of the DNA

Question 5

a change in a dna triplet will change

Answer 5

A change in a DNA triplet will change the bases in the corresponding mRNA codon which may add a different amino acid to the polypeptide chain

Question 6

in some cases a stop codon may be produced which would

Answer 6

In some cases, a stop codon may be produced, which would produce a shorter polypeptide chain, which cannot form the CFTR protein

Question 7

If there is a different sequence of amino acid in the polypeptide

Answer 7

If there is a different sequence of amino acid in the polypeptide, this changes the sequence of R groups. This may change the bonding between these groups in the protein, changing the tertiary structure and the 3D shape of the protein, resulting in a faulty CFTR protein

Question 8

the fault CFTR protein can’t

Answer 8

The faulty CFTR protein cannot transport chloride ions, so these ions
cannot move out of epithelial cells through the CFTR protein to enter mucus, therefore sodium ions do not move out of cells and into the mucus, and consequently water cannot move out of cells into mucus by the process of osmosis

Question 9

mucus becomes

Answer 9

Mucus becomes thicker/ stickier /more viscous than normal, blocking parts of the body, which impairs the functioning of the respiratory, digestive and reproductive systems