Cerebellum Flashcards
3 principle motor functions of cerebellum
Tone
Posture and balance
Co-ordination of movements
From which emrbyological precursor does cerebellum arise?
From metencerphalic portion of rhombencephalon
What are the three principle lobes of cerebellum
Anterior
Posterior
Flocullus
Function of flocculonodular lobe
Balance (most primitive) of head and eyes
Archicerebellum=
Floculonodular lobe
Paleocerebellum=
Anterior lobe
Function of anterior lobe of cerebellum?
Tone
Neocerebellum=
Posterior lobe
Function of posterior lobe
Co-ordination of movement
Which fissure divides anterior and posterior cerebellar lobes?
Primary fissure
Which fissure separates posterior lobe from floculonodular lobe
Posterolateral fissure
What is the name of the area of the cerebellum adjacent to the vermis?
Paravermal area/ Intermediate zone
What is the arrangement of the sensory homunculus of the cerebellum
In which portion of the cerebellum is the control of trunk and axial musculature found?
Vermal area
Where in the cerebellum is the control of the hands or feet?
Paravermal area
What are the two types of grey matter in the cerebellum?
Cerebellar cortex
Deep cerebellar nuclei
How can the afferent fibres to cerebellum be classified?
Those coming from alll portions of CNS - mossy fibres
Those coming from inferior olivary nucleus (olivocerebellar fibres- climbing fibres)
Spartans are climbing the olive tree to cerebellar cortex
Olivocerebellar fibres= climbing fibres
Spartans- contain aspartate
All fibres which enter cerebellum are
Exctitatory
Which neurotransmitters are released by mossy fibres?
Glutamate
Layers of cerebellar cortex
My
Personal
Garden
Molecular
Purkinje
Granular
With what must all fibres entering cerebllar cortex synapse before entering cortex?
Deep cerebellar nuclei
With what deeper structure do cells from the purkinje layer synapse?
Is this inhibitory or excitatory?
Deep cerebellar nuclei
Inhibitory (GABA)
With what do climbing fibres synape?
Dendrites of Purkinje cells in molecular layer of cerebellar cortex
Output from cerebellum is from which structures?
Deep cerebellar nuclei
With what layer of cortex do mossy fibres synapse?
Multiple dendrites with multiple granular cells
What happens to axons from the granular cell layer
Ascend to molecular layer and connects with millions of Purkinje cell dendrites as parallel fibres
Ratio of climbing fibre connections to Purkinje cells
1:1
Granular cells release which neurotransmitter?
Glutamate
What are the inhibitory cells of the granular layer of the cerebellar cortex?
What stimulates them?
Golgi cells (stimulated by parallel fibres of granular cells and directly by mossy cells)
Inhibitory to granular cells
What are the inhibitory cells of the molecular layer?
Basket and stellate cells
Function of stellate and basket cells
Inhibit Purkinje cells surrounding that activated by parallel fibres from the granular cell, dampens down background noise in effect.
Spinocerebellum=
Paleocerebellum
Archicerebellum=
Vestibulocerebellum
Neocerebelllum=
Cerebrocerebellum
What happens to fibres from vestibular system
Enters vestibular apparatus then cerebellum
Some enter cerebellum directly
Via which cerebellar peduncle do vestibulocerebellar fibres enter cerebellum?
Inferior cerebellar peduncle
What happens to fibres from the deep nucleus of floculonodular lobe?
Some return to vestibular apparatus (cerebellovestibular fibres)
Fibres from the vestibular apparatus descend as vestibulospinal tract
some interact with reticular nuclei and descend in reticulospinal tract
Some ascend from vestibular apparatus and influence CN3, 4, 6 as MLF
What is the function of the vestibulospinal tract
Extensor muscle tone
What is the deep nucleus of the floculonodular lobe?
Fastigial nucleus
Through which cerebellar peduncle does the dorsal spinocerebellar tract pass?
Ipsilateral inferior cerbellar peduncle
What is the nucleus of 2o spinocerebellar neurones?
Nucleus of Clark
How does proprioceptive information from upper limb enter cerbellum?
Cuneocerebellar pathway
How does ventral spinocerebellar pathway enter cerebellum?
Superior cerebellar peduncle then decussate again
Where do ventral spinocerebellar neurones decussate?
At level of spinal cord and again in the cerebellum
What additional information is carried by ventral spinocerebellar tract to cerebellum?
Carries information about descending corticospinal information
What is the most lateral deep cerebellar nuclei?
Dentate nucleus
What is the most medial deep cerebellar nuclei?
Fastigial
Deep cerebellar nuclei from lateral to medial
Don’t eat greasy food
Dentate
Emboliform
Globose
Fastigial
With which system is the fastigial nucleus intimately associated?
Vestibulocerebellar
With which system are the globose and emboliform nuclei associated?
Spinocerebellum
Dentate nucleus associated with which cerebellum
Cerebrocerebellum/neocerebellum
What are the interposed nuclei?
Globose and emboliform
What is the output of the interposed nuceli?
Spinocerebellar outflow:
Cerebellorubrothalamic fibres
Cerebellothalamic fibres
Cerrebellorubrospinal fibres
What is the output of neocerebellum?
Via dentate nucleus:
Dentorubrothalamic fibres
Dentothalamic fibres
What are the aminergic fibres of the cerebellum/
There are serotonin containing axons from the raphe nuclei of brainstem
Noradrenergive fibres from the locus coeruleus