Cellular Signals Flashcards
Signalling molecules
Transmit information about an internal or external stimulus to other cells.
Animal hormones
Hormones are produced by animal organs or glands. Involve autocrine, paracrine or endocrine modes of transmission.
Neurotransmitters
Transmit signals to various types of cells that form synapses with neurons. Hydrophilic and paracrine transmission mode.
Cytokines
Produced by immune cells (macrophages and lymphocytes).
Pheromones
Excreted outside the organism and diffuse through the air to other individuals of the same. Species.
Abscisic acid
Visible effect: seed and bud dormancy, drought tolerance and apical dominance.
Auxins
Visible effect: shoot tip bends towards the light, roots grow downwards, apical dominance.
Cytokinins
Visible effect: growth of lateral branches
Gibberellins
Visible effect: elongation of stems, leaf expansion, seed germination, fruit and flower mutation.
Ethene
Visible effect: increases sugar content of fruit (ripening), fruit and leaf drop off.
Signal transduction
The process of transmitting a signal into or out of a cell, or changing the form of a signal into another form. (Second messengers, when signalling molecules bind to a cell surface receptor and the conversion of an action potential to neurotransmitters).
Signal transduction steps
- Reception
- Transduction
- Cellular response
Hydrophilic receptors location
On the membrane.
Hydrophilic receptors location
In the cytosol
Apoptosis
Programmed cell death
Mitochondrial pathway
Apoptosis triggered by cell damage; signal comes from within the cell.
Death receptor pathway
Triggered by cytokines; signal comes from within the cell.
Cascades
Enzymes that physically break down the components of te cell during apoptosis.
Steps of apoptosis
- Separation from adjacent cells.
- Collapse of cell’s cytoskeleton
- Cell shrinkage.
- Breakdown of organelles and nucleus.
- Blabbing of the plasma membrane.
- Budding of plasma membrane-bound vesicles called apoptosis bodies.
- Phagocytosis of the apoptotic bodies by macrophages etc.
Inhibited apoptosis examples
Syndactyly & cancers.
Cancer
Unregulated and abnormal cell growth and division.
Excessive apoptosis example
Alzheimer’s disease