Cellular immunity and histocompatibility

Question 1

what is CD8

Answer 1

CD8 cytotoxin
is a t lymphocyte

it is responsible for directly killing
a pathogen

Question 2

what is CD4

Answer 2

CD4
is a helper t lymphocyte

it is responsible for inflammatory response of the other WBC’s

Question 3

What is the role of the thymus

Answer 3

primary lymphoid organ.

Hemopoietic lymphoid pressurors migrate from the bone marrow to the thymus

pressuror turn into mature T lymphocytes

Thymus educates a minority of the pressurors

majority of the pressurors die within the thymus

Question 4

describe the roll of an Cytotoxic T cell (CD8)

Answer 4

Cytotoxic T cells kill nonself cells.

Cytotoxic T cell sees a change in the MHC class 1 or the ‘neoantigen’ and decides to kill the molecle

Question 5

what are the two different of MHC restrictions

Answer 5

antigens encoded from self

or antigens that are encoded from nonself

Question 6

Describe MHC class 1

Answer 6

a, b, c

Question 7

Describe MHC class 2

Answer 7

Dr, Dp, Dq

Question 8

Who comes to attack MHC class 1

Answer 8

CD8

Question 9

who comes to attach MHC class 2

Answer 9

CD4

Question 10

Describe how CD4 works

Answer 10

CD4 binds to MHC class 2 on a virus

virus is presented with extracellular bacteria

CD4 produces cytokines and proliferates

= increase in the amount of CD4

Question 11

Describe how CD8 works

Answer 11

CD8 views MHC class 1

MHC class 1 is internal virus.

Antigens are presented on the virus

CD8 attaches to the virus and punctures it.

= perforin of the cell and punch’s holes that kill the cell.

Question 12

Describe the issues faced with MHC polymorphism

Answer 12

tissue transplatantion is difficult and MHC is linked to many autoimmune diseases