Cells and Tissues of the Immune System Flashcards

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1
Q

What is haematopoiesis

A

the formation of blood cellular components. (All cellular blood components are derived from haematopoietic stem cells)

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2
Q

in what tissue are pluripotent hematopoietic stem cells found

A

bone marrow

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3
Q

common lymphoid progenator cells specialise into which 3 immune cell types

A

B cells
T cells
NK cells

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4
Q

erythroblasts are precursor cells to which cell

A

erythrocytes (RBCs)

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5
Q

What are the 3 effector cells?

A

plasma cell
activated T cell
activated NK cell

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6
Q

megakaryocytes are precursors to which component of blood

A

platelets

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7
Q

where are the granulocytes found?

A

the blood

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8
Q

a neutrophil is part of which hematopoietic lineage?

A

granulocyte

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9
Q

an eosinophil is part of which hematopoietic lineage?

A

granulocyte

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10
Q

a basophil is part of which hematopoietic lineage?

A

granulocyte

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11
Q

a monocyte is part of which hematopoietic lineage?

A

granulocyte

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12
Q

common myeloid progenitor cells produce which 2 types of progenitor cell

A

granulocyte/macrophage progenitor

megakaryocyte/erythrocyte progenitor

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13
Q

unknown precursor of mast cells are part of which hematopoietic lineage?

A

granulocytes

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14
Q

which immune cells are found in the lymph nodes

A

B cell
T cell
NK cell

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15
Q

immature dendritic cells found in the blood end up as what and where are they found?

A

mature dendritic cells in tissues and lymph nodes

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16
Q

where are mast cells found

A

in tissues

17
Q

where are macrophages found

A

in tissues

18
Q

what is the normal cell % for basophils

A

<1%

19
Q

what is the normal cell % for eosinophils?

A

1-3%

20
Q

what is the normal cell % for monocytes?

A

1-6%

21
Q

what is the normal cell % for lymphocytes

A

20-40%

22
Q

what is the normal cell % for neutrophils

A

50-70%

23
Q

what is the normal cell count for RBCs

A

5.0 x 10~6 cells/mm3

24
Q

what is the normal cell count for platelets

A

2.5 x 10~5 cells/mm3

25
Q

what is the normal cell count for leukocytes

A

7.3 x 10~3 cells/mm3

26
Q

which progenitor cells produces macrophages

A

monocytes

27
Q

where is the alveolar macrophage found?

A

lung tissue

28
Q

where are histiocytes found

A

connective tissue

29
Q

where are mesangial cells found

A

kidney

30
Q

where are microglial cells found

A

brain

31
Q

where are kupffer cells found

A

liver

32
Q

where are osteoclasts found

A

bone

33
Q

Stem cell –> ? –> ? —> macrophage

A

monoblast

monocyte

34
Q

what do macrophages differentiate into?

A

microglia
kupffer cells
alveolar macrophages
osteoclasts etc

35
Q

what do macrophages turn into upon immune activation?

A

activated macrophages