Cells and Tissues of the Immune System Flashcards
What is haematopoiesis
the formation of blood cellular components. (All cellular blood components are derived from haematopoietic stem cells)
in what tissue are pluripotent hematopoietic stem cells found
bone marrow
common lymphoid progenator cells specialise into which 3 immune cell types
B cells
T cells
NK cells
erythroblasts are precursor cells to which cell
erythrocytes (RBCs)
What are the 3 effector cells?
plasma cell
activated T cell
activated NK cell
megakaryocytes are precursors to which component of blood
platelets
where are the granulocytes found?
the blood
a neutrophil is part of which hematopoietic lineage?
granulocyte
an eosinophil is part of which hematopoietic lineage?
granulocyte
a basophil is part of which hematopoietic lineage?
granulocyte
a monocyte is part of which hematopoietic lineage?
granulocyte
common myeloid progenitor cells produce which 2 types of progenitor cell
granulocyte/macrophage progenitor
megakaryocyte/erythrocyte progenitor
unknown precursor of mast cells are part of which hematopoietic lineage?
granulocytes
which immune cells are found in the lymph nodes
B cell
T cell
NK cell
immature dendritic cells found in the blood end up as what and where are they found?
mature dendritic cells in tissues and lymph nodes
where are mast cells found
in tissues
where are macrophages found
in tissues
what is the normal cell % for basophils
<1%
what is the normal cell % for eosinophils?
1-3%
what is the normal cell % for monocytes?
1-6%
what is the normal cell % for lymphocytes
20-40%
what is the normal cell % for neutrophils
50-70%
what is the normal cell count for RBCs
5.0 x 10~6 cells/mm3
what is the normal cell count for platelets
2.5 x 10~5 cells/mm3
what is the normal cell count for leukocytes
7.3 x 10~3 cells/mm3
which progenitor cells produces macrophages
monocytes
where is the alveolar macrophage found?
lung tissue
where are histiocytes found
connective tissue
where are mesangial cells found
kidney
where are microglial cells found
brain
where are kupffer cells found
liver
where are osteoclasts found
bone
Stem cell –> ? –> ? —> macrophage
monoblast
monocyte
what do macrophages differentiate into?
microglia
kupffer cells
alveolar macrophages
osteoclasts etc
what do macrophages turn into upon immune activation?
activated macrophages
