Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Mbb231 > Cell Motility-MT > Flashcards

Cell Motility-MT Flashcards

1
Q

Cell motility

A

Movement of cell
Movement environment
Movement component of cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Motility occur at —,—,— level

A

Tissue
Cellular
Subcellular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

MT and MF provide scaffold for

A

Motor protein
Mechanoemzymes
To produce motion at molecular level

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

MT intracellular movement

A

Mitotic spindle in separation of chromosomes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cell contractility

A

Shortening of muscle cells, specialized form of motility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Two eukaryotic motility system

A

1-MT and Motor protein kinesins and dyenins
2-Interactions between actin MF and myosin motor proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Motor proteins convert

A

Chemical energy (ATP) into mechanical energy (force)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Molecular proteins

A

Move unidirectionally along cytoskeletal components

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

No motor protein associated with

A

IF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Motors undergo

A

Cycle ATP hydrolysis, release ADP, acquisition of new ATP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Motor protein transduce changes in shape to

A

Movement of filaments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Motor protein are subjected to

A

Tremendous friction
Stop when energy runs out

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Motor are processive

A

Move for significant distances
Until energy runs out

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Kinesin

A

Anterograde MT motor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Dynenin

A

Retrograde MT motor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Dyenin has —— than kinesin don’t have

A

Extra dota lule tor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

MT provide

A

Rigid set of tracks for transport

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Traffic toward - end

A

Inbound

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Traffic toward + end

A

Outbound

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Movement vesicles and organelle along MT

A

Fast axonal transport

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Motors are responsible for

A

Organelle transport and correct localization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Two proteins responsible for fast axonal transport

A

Kinesin I: ATP-dependent transport toward plus end called anterograde
Cytoplasmic dyenin: move cargo toward minus end called retrograde

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Kinesins movement is coupled to

A

ATP hydrolysis

24
Q

Kinesin 1 is tetramer

A

2 heavy chains
2 light chains

25
Q

Kinesin 1 has four region

A

-globular head region: ATP hydrolyzing engine
-neck region: attach head to stalk
-coiled helical stalk region: provide flexibility
-light chain region: attach kinesin to proteins

26
Q

KRP head

A

Evolutionarily conserved
Similar motor function

27
Q

KRP tail

A

Highly divergent
(Reflecting the cargo diversity)

28
Q

All kinesin have

A

Motor domains

29
Q

Kinesins are classified based on

A

Structure

30
Q

Some kinesins from —— some ——

A

Homodimer
Heterodimer

31
Q

Family —— is minus end directed

A

Kinesin 14

32
Q

Kinesin mode of movement ( hand-over-hand)

A

1- leading heavy chain bind ATP
2- ATP binding causes conformational change (trailing heavy chain swing forward)
3- trailing heavy chain find new MT binding site and release ADP
4- new trailing head hydrolyze atp to adp and p

33
Q

Dyneins

A

Cytoplasmic dyneins: high processivity toward minus end
Dynein doesn’t directly interact with cargo: requires adaptor molecule: dynactin and spectirin

axonemal Dyneins: generate motility in cilia (power stroke)

34
Q

Kinesin and dynein

A

Move similar materials inopposite direction over same railway
Organelles may bind kinesin and dynein spontaneously

35
Q

Cilia

A

-Most cell have one to many cilia
-Both unicellular and multicellular eukaryotes
-Generate a force perpendicular ti cilium

36
Q

Cilia kinds

A

Motile cilia: move fluid through tracts
Non-motile: cilia having sensory functions

37
Q

Flagella

A
  • move cell through fluid environment
  • same diameter but much longer than cilia
  • one or few per cell
  • force generated parallel to flagellum
38
Q

Cilium/flagella share common structure

A

Axoneme

39
Q

Cilium/flagellum emrge from ——

A

Basal body

40
Q

Between axoneme and basal body

A

Transition zone

41
Q

Transition zone

A

MT begin characteristic of axoneme

42
Q

Axoneme

A

Nine peripheral MT doublets surrounding central pair of single MT

43
Q

Each MT doublet

A

One 13 subunit
One 10-11 subunit

44
Q

Central tubes in axoneme are enclosed by

A

Sheath connected to peripheral doublets

45
Q

Doublets are connected to each other by

A

nexin
Elastic protein based link

46
Q

Axonemal dyneins

A

Project from A MT
Pair of arms — inner and outer

47
Q

Assembly and dis’s assembly of cilium and flagellum required

A

Transport material to and from distal end

48
Q

Movement of structural components called

A

Intraflagellar transport (IFT)
Occurs between peripheral doublet and cell membrane

49
Q

Kinesin-2

A

(Plus end directed motor)
Pulls IFT toward cilium

50
Q

Cytoplasmic dynein

A

(Minus end directed motor)
Return IFT trains to cell body

51
Q

Axonemal dynein

A

Cause MT sliding within the axoneme allowing cilia and flagella to bend (no change in overall length of MT)

52
Q

Stem axonemal dynein

A

Tightly anchored to outer surface of A tubule

53
Q

Globular head and stalk of axonemal dynein

A

Project toward B tubule of neighboring doublet

54
Q

Axonemal dynein

A

Exert force on neighbouro g Mt pulling A tubule toward minus end
some flexibility but not really moving

55
Q

Presence of nexin linkage prevent ——

A

Sliding the doublet past each other

56
Q

At any given time

A

Axonemal dynein on one side of axoneme are active, while on other side is inactive

57
Q

Primary cilia are used in ——

A

Sensory structure

Mbb231 (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions