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I and I Midterm > Cell Mediate Activation > Flashcards

Cell Mediate Activation Flashcards

1
Q

Expresses CD45RO and lacks CD45RA

A

Memory cells

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2
Q

Low CD62L and high CD44

A

Memory

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3
Q

Low CD44 and high CD62L

A

Naive

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4
Q

Lymphocyte extravasation molecules and what they match up with

A

On the Lymphocyte: LFA1, L selectin,

On endothelial: Gly-CAM1, ICAM1, CD34

LFA1:ICAM1

GlyCAM1:Lselectin

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5
Q

What does CD4 stabilize

A

MHC class II

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6
Q

What does CD8 stabilize

A

MCH 1

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7
Q

B7.1 aka

A

CD80

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8
Q

B7.2 aka

A

CD28

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9
Q

APC co-stimulatory molecules

A

B7.1 and B7.2

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10
Q

What do the co-stimulatories do

A

They tell cell to keep surviving, growing, proliferating.

It does this by upregulating IL2

IL2 is a survival and proliferation factor into effector

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11
Q

If there is no B7.1/2 interaction what happens

A

Inactivates T cell. Aka ANERGY

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12
Q

CD28 is on ____ cell

A

T

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13
Q

B7.1/2 is on ____ cell

A

APC (DC)

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14
Q

What makes IL2 receptor have high affinity for IL2

A

CD25

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15
Q

What does CD40:CD40L interaction do to B cells

A

Promotes proliferation
Antibody secretion
Class switching

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16
Q

What does CD40:CD40L interaction do to macrophages

A

Activation
killing of phagocytoses microbes
Makes macrophages better killers

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17
Q

_____ makes CD4 an effector

A

CD40L

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18
Q

Mutations in CD40 or CD40L cause ____ syndrome. Why?

A

Hyper IgM syndrome

Bc you cant class switch to IgG

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19
Q

When you have mutated CD40 or CD40L you have a ton of IgM what else is affected, why

A

Cell mediated immunity is also wack bc CD40:CD40L activate macrophages normally. But now they wont be activated.

20
Q

IL12 cytokine creates ____ antigen activated T Cell and _____

A

STAT4 + STAT1

Th1 cell

21
Q

IFNγ cytokine creates ____ antigen activated T Cell and _____

A

STAT4 + STAT1
Th1 cell

22
Q

IL4 cytokine creates ____ antigen activated T Cell and _____

A

STAT6
Th2 cell

23
Q

TGF-β cytokine creates ____ antigen activated T Cell and _____

A

STAT3
Th17 cell

24
Q

Th1 cells are induced by

A

INTRACELLULAR pathogens

25
Q

Th1 is stimulated by ____ cytokine and it produces _____ cytokine

A

IL12 and IFNγ

IFNγ

26
Q

The IFNγ Th1 cells produce do what

A

Activate macrophages for cytotoxicity

Work with CD40L
Together they make the macrophage more sensitive to IFNγ

27
Q

Th2 induced by

A

Parasites and helminths

28
Q

Th2 is stimulated by ____ cytokine and it produces _____ cytokine

A

IL4

IL4, IL5, IL13

29
Q

IL4 of produced by ____ induces

A

Th2
Class switching to IgE

30
Q

IL5 produced by ____ induces

A

Th2

Activates eosinophils and mast cells for degranulation

31
Q

What is responsible for allergy (type I hypersensitivity)

A

Th2

32
Q

Th17 induced by

A

Extracellular bacteria

33
Q

Th17 is stimulated by ____ cytokine and it produces _____ cytokine

A

IL1, IL6, IL23

IL17, IL22

34
Q

IL17 produced by ____ induces

A

Th17

Recruits neutrophils

35
Q

IL22 produced by ____ induces

A

Th17

Induces epithelial production of defensins
Maintains epithelial integrity
Promotes epithelial repair

36
Q

Have L-selectin and CCR7 on them

A

Naive T cells

37
Q

Do not have CD25, CD44, CD69 on them

A

Naive T cells

38
Q

Do not have CD45RO but do have CD45RA

A

Naive T cells

39
Q

Express CD25

A

Effector T cells

40
Q

Express CD40

A

Effector T cells

41
Q

Express CD69

A

Effector T cells

42
Q

No CCR7

A

effector T cells

43
Q

Perforins

A

Form pores in target cell

44
Q

Granzymes

A

Activate caspases which induce apoptosis

45
Q

Antibody dependent cellular cytotoxicity

A

CD16 - NK cells

I and I Midterm (19 decks)

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